帕金
粒体自噬
病理生理学
神经科学
疾病
帕金森病
品脱1
重性抑郁障碍
萧条(经济学)
心理学
医学
生物
自噬
内科学
遗传学
扁桃形结构
细胞凋亡
宏观经济学
经济
标识
DOI:10.1016/j.neuint.2024.105808
摘要
Depression is a complex mood disorder with multifactorial etiology and is also the most frequent non-motor symptom of Parkinson's disease. Emerging research suggests a potential link between mitochondrial dysfunction and the pathophysiology of major depressive disorder. By synthesizing current knowledge and research findings, this review sheds light on the intricate relationship between Parkin, a protein classically associated with Parkinson's disease, and mitochondrial quality control mechanisms (e.g., mitophagy, mitochondrial biogenesis, and mitochondrial dynamic), specifically focusing on their relevance in the context of depression. Additionally, the present review discusses therapeutic strategies targeting Parkin-medicated mitophagy and calls for further research in this field. These findings suggest promise for the development of novel depression treatments through modulating Parkin-mediated mitophagy.
科研通智能强力驱动
Strongly Powered by AbleSci AI