Regulation of NLRP3 inflammasome and Caspase-3/4/11 by 2′,4′-dihydroxychalcone contributes to anti-colorectal cancer

Chronic inflammation is closely related to the occurrence and progression of many cancers, especially colorectal cancer (CRC), which can be triggered by repeated and sustained induction of colitis in mice. CRC is a typical type of cancer that can be caused by inflammation and NLRP3 inflammasome dysregulation plays a certain role in the pathogenesis of CRC.