Percent Predicted vs. Absolute Six-Minute Walk Distance as Predictors of Lung Transplant-Free Survival in Fibrosing Interstitial Lung Diseases

医学 比例危险模型 特发性肺纤维化 队列 肺移植 危险系数 内科学 回顾性队列研究 生存分析 肿瘤科 置信区间
作者
Umberto Zanini,Jane Ding,Fabrizio Luppi,Karina Kaur,Niccolò Anzani,Giovanni Franco,Giovanni Ferrara,Meena Kalluri,Marco Mura
出处
期刊:Lung [Springer Science+Business Media]
标识
DOI:10.1007/s00408-024-00748-5
摘要

Abstract Introduction Fibrosing interstitial lung diseases (ILDs) often progress despite treatment and become life-threatening, with lung transplant (LTx) remaining the only curative option. Six-minute walk distance (6MWD) is increasingly recognized as reliable predictor of clinical course, especially when longitudinally considered. The use of reference equations to express 6MWD as percent predicted (6MWD%) has not been previously studied in fibrosing ILDs. We sought to investigate whether the prognostic power of 6MWD% is superior to that of 6MWD expressed in meters (6MWD-m). Methods A retrospective, multicenter cohort analysis was conducted on both idiopathic pulmonary (IPF) and non-IPF fibrosing ILD patients. Patients were divided into a discovery ( n = 211) and a validation ( n = 260) cohort. Longitudinal changes of 6MWD% and lung function parameters were simultaneously considered. LTx-free survival at 3 years from baseline was the endpoint. Competing risks of death and LTx were considered. Results Baseline 6MWD% and its longitudinal changes were significant predictors of LTx-free survival and independent from lung function variables. In both cohorts, on multivariate cox proportional hazard regression analysis, receiver operating characteristics analysis and Kaplan–Meier estimates, 6MWD% was consistently, but only slightly superior to 6MWD-m as a predictor of LTx-free survival. Conclusion 6MWD% has only a slight, yet detectable advantage over 6MWD-m as a predictor of survival in fibrosing ILDs. Utilizing 6MWD% may aid in risk stratification, treatment monitoring, and LTx timing optimization. However, available reference equations do have predicting limitations. Refined predictive equations and standardizing reporting practices are therefore needed to further enhance the clinical utility of 6MWD% in fibrosing ILDs.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Rick发布了新的文献求助10
刚刚
刚刚
灯飞发布了新的文献求助10
刚刚
1秒前
campus发布了新的文献求助10
2秒前
军帽发布了新的文献求助10
3秒前
是子子子子枫完成签到,获得积分10
3秒前
4秒前
苹果白凝发布了新的文献求助50
4秒前
麻烦~发布了新的文献求助10
5秒前
7秒前
传奇3应助岁岁采纳,获得10
9秒前
10秒前
12秒前
MJS完成签到,获得积分10
13秒前
屿若发布了新的文献求助10
13秒前
共享精神应助刘无敌采纳,获得10
13秒前
wtt发布了新的文献求助10
13秒前
CC关注了科研通微信公众号
14秒前
sn完成签到,获得积分10
16秒前
bkagyin应助飞翔的企鹅采纳,获得10
16秒前
16秒前
虞滢滢发布了新的文献求助10
16秒前
量子星尘发布了新的文献求助10
17秒前
麻烦~完成签到,获得积分10
17秒前
18秒前
Li chun sheng完成签到,获得积分10
20秒前
3366发布了新的文献求助10
21秒前
22秒前
CipherSage应助谨言采纳,获得10
23秒前
qqqqqqy完成签到,获得积分10
27秒前
BDMAXPK发布了新的文献求助10
28秒前
彭于晏应助Shrine采纳,获得10
30秒前
深情的皮皮虾完成签到 ,获得积分10
33秒前
i_jueloa完成签到,获得积分10
33秒前
34秒前
36秒前
36秒前
岁岁完成签到,获得积分10
38秒前
木乙发布了新的文献求助10
39秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975658
求助须知:如何正确求助?哪些是违规求助? 3519986
关于积分的说明 11200481
捐赠科研通 3256410
什么是DOI,文献DOI怎么找? 1798247
邀请新用户注册赠送积分活动 877490
科研通“疑难数据库(出版商)”最低求助积分说明 806376