光热治疗
封锁
免疫疗法
免疫原性细胞死亡
光动力疗法
免疫检查点
CD8型
医学
抗原
免疫系统
化学
癌症研究
免疫学
材料科学
纳米技术
内科学
受体
有机化学
作者
Yadi Fan,Ruolin Zhang,Jingyu Shi,Tian Feng,Yu Zhang,Li Zhang,Guangfu Liao,Mo Yang
标识
DOI:10.1016/j.jcis.2024.09.020
摘要
One of the primary challenges for immune checkpoint blockade (ICB)-based therapy is the limited infiltration of T lymphocytes (T cells) into tumors, often referred to as immunologically "cold" tumors. A promising strategy to enhance the anti-tumor efficacy of ICB is to increase antigen exposure, thereby enhancing T cell activation and converting "cold" tumors into "hot" ones. Herein, we present an innovative all-in-one therapeutic nanoplatform to realize local mild photothermal- and photodynamic-triggered antigen exposure, thereby improving the anti-tumor efficacy of ICB. This nanoplatform involves conjugating programmed death-ligand 1 antibody (aPD-L1) with gadolinium-doped near-infrared (NIR)-emitting carbon dots (aPD-L1@GdCDs), which displays negligible cytotoxicity in the absence of light. But under controlled NIR laser irradiation, the GdCDs produce combined photothermal and photodynamic effects. This not only results in tumor ablation but also induces immunogenic cell death (ICD), facilitating enhanced infiltration of CD8
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