视神经
衰老
视网膜
视网膜神经节细胞
细胞生物学
生物
下调和上调
程序性细胞死亡
小胶质细胞
神经科学
炎症
病理
医学
免疫学
基因
遗传学
细胞凋亡
作者
Yao Yao,Xin Bin,Yanxuan Xu,Shaowan Chen,Si Chen,Xiang‐Ling Yuan,Yingjie Cao,Tsz Kin Ng
摘要
Traumatic optic neuropathy refers to optic nerve (ON) injury by trauma, including explosion and traffic accident. Retinal ganglion cell (RGC) death is the critical pathological cause of irreversible visual impairment and blindness in ON injury. We previously investigated the patterns of 11 modes of cell death in mouse retina post-ON injury. Here we aimed to identify additional signalling pathways regulating RGC survival in rodents post-ON injury. RNA sequencing analysis identified the upregulation of inflammation and cellular senescence-related genes in retina post-ON injury, which were confirmed by immunoblotting and immunofluorescence analyses. Increased expression of senescence-associated β-galactosidase (SA-βgal) in RGCs and activation of microglia were also found. Transforming growth factor-β receptor type II inhibitor (LY2109761) treatment suppressed p15
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