From backstage to the spotlight: γδT cells in cancer

γδT cells represent a group of immune cells that are understudied but whose utility has been recognized for cancer immunotherapy purposes. Recent studies have highlighted a critical role for these cells in tumor initiation, growth, and metastasis and revealed an increasingly complex biology of γδT cell subsets that is context and tissue specific. We discuss here how γδT cell subsets are regulated, their interaction with cancer and other immune cells, and the implications from these latest discoveries for people with cancer.