Effect of curcumin on malignant hepatocytes and mitochondria studied using atomic force microscopy

姜黄素 线粒体 生物物理学 细胞 化学 细胞生物学 细胞粘附 生物 生物化学
作者
Shengli Zhang,Ying Wang,Bowei Wang,Yi Zeng,Jiani Li,Xingyue Wang,Cuihua Hu,Zhankun Weng,Zuobin Wang
出处
期刊:Micron [Elsevier]
卷期号:177: 103573-103573
标识
DOI:10.1016/j.micron.2023.103573
摘要

Mitochondria are emerging as potential targets for the cancer treatment. In this study, the effects of curcumin on the activity, migration, and mitochondrial membrane potential (MMP) of malignant hepatocytes (SMMC-7721 cells) were determined using cell viability, migration, and MMP assays. Changes in the morphology and biomechanics of SMMC-7721 cells and their mitochondria were studied using both optical microscopy and atomic force microscopy (AFM). The cell survival rate, migration and MMP depended on the concentration of curcumin. Optical microscopy studies showed that curcumin altered the cell morphology. AFM studies showed that the changes in the morphology and nanomechanics of SMMC-7721 cells and their mitochondria, were induced by curcumin. As the concentration of curcumin increased, the cell length, width, and adhesion decreased, but the height, roughness and Young's modulus increased. In contrast, the mitochondrial length, width, height and roughness increased, but the adhesion and Young's modulus decreased. There was a close relationship between mitochondria and cells in terms of function, morphology and biomechanics. This study shows the effects of curcumin on SMMC-7721 cells and their mitochondria from biology and biophysics perspectives. The findings aid in comprehensively understanding the interactions between mitochondria and malignant hepatocytes.
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