Round Window Niche Veil is Visible on High‐Resolution Computed Tomography and a Predictor of Local Drug Efficacy to Inner Ear

医学 圆窗 椭圆窗 颞骨 外淋巴 高分辨率计算机断层扫描 半规管 内耳 前庭系统 放射科 软组织 前庭导水管 核医学 中耳 外科 镫骨 计算机断层摄影术
作者
Shipei Zhuo,Yong Li,Bozhen Cui,Yuxiang Liu,Jingman Deng,Jintao Lou,Jianpeng Yuan,Yu Si,Zhigang Zhang
出处
期刊:Laryngoscope [Wiley]
卷期号:134 (3): 1396-1402 被引量:5
标识
DOI:10.1002/lary.31006
摘要

Objectives To determine the morphologies and effect of the round window niche veil (RWNV) on local drug delivery efficacy and develop diagnostic criteria on high‐resolution computed tomography (HRCT). Methods Patients diagnosed with otosclerosis, bilateral profound sensorineural hearing loss or vestibular schwannoma were enrolled from 2019 to 2022, receiving temporal bone HRCT scanning, and anatomic variations of RWMV were summarized intraoperative. For patients with vestibular schwannoma, 1 mL of dexamethasone solution (4 mg/mL) was administered via facial recess during operation, and samples of perilymph were collected to analyze. The diagnostic criteria of RWNV on HRCT were developed and verified. Results A total of 85 patients were enrolled. RWNV was observed in 54 cases intraoperatively with an incidence of 63.5% (95% CI, 52.9%–73.0%). The median perilymph concentrations were 4.86‐fold higher in the group without RWNV than with RWNV ( p < 0.0001). RWNV could be visualized on HRCT with a window width of 3500–4500 HU and a window level of 300–500 HU. The characteristic features were as follows: (1) a thin soft tissue shadow could be seen at the entrance of the round window niche (RWN); (2) it was visible in at least 2 consecutive layers along the upper margin of RWN from top to bottom; (3) it was discontinuous with the adjacent bone margin. The sensitivity and specificity of the diagnostic criteria were 77.8% and 93.6%, respectively. Conclusion RWNV could reduce local dexamethasone diffusion efficacy to the inner ear, which could be diagnosed on HRCT and used as a predictor of local drug delivery efficacy to the inner ear. Level of Evidence 3 Laryngoscope , 134:1396–1402, 2024
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