Prediction of high Ki-67 proliferation index of gastrointestinal stromal tumors based on CT at non-contrast-enhanced and different contrast-enhanced phases

主旨 对比度(视觉) 医学 无线电技术 放射科 接收机工作特性 神经组阅片室 核医学 间质细胞 病理 人工智能 计算机科学 内科学 神经学 精神科
作者
Zhenhui Xie,Shiteng Suo,Wang Zhang,Qing‐Wei Zhang,Yongming Dai,Yang Song,Xiaobo Li,Yan Zhou
出处
期刊:European Radiology [Springer Science+Business Media]
卷期号:34 (4): 2223-2232 被引量:6
标识
DOI:10.1007/s00330-023-10249-3
摘要

Abstract Objectives To evaluate and analyze radiomics models based on non-contrast-enhanced computed tomography (CT) and different phases of contrast-enhanced CT in predicting Ki-67 proliferation index (PI) among patients with pathologically confirmed gastrointestinal stromal tumors (GISTs). Methods A total of 383 patients with pathologically proven GIST were divided into a training set ( n = 218, vendor 1) and 2 validation sets ( n = 96, vendor 2; n = 69, vendors 3–5). Radiomics features extracted from the most recent non-contrast-enhanced and three contrast-enhanced CT scan prior to pathological examination. Random forest models were trained for each phase to predict tumors with high Ki-67 proliferation index (Ki-67>10%) and were evaluated using the area under the receiver operating characteristic curve (AUC) and other metrics on the validation sets. Results Out of 107 radiomics features extracted from each phase of CT images, four were selected for analysis. The model trained using the non-contrast-enhanced phase achieved an AUC of 0.792 in the training set and 0.822 and 0.711 in the two validation sets, similar to models trained on different contrast-enhanced phases ( p > 0.05). Several relevant features, including NGTDM Busyness and tumor size, remained predictive in non-contrast-enhanced and different contrast-enhanced images. Conclusion The results of this study indicate that a radiomics model based on non-contrast-enhanced CT matches that of models based on different phases of contrast-enhanced CT in predicting the Ki-67 PI of GIST. GIST may exhibit similar radiological patterns irrespective of the use of contrast agent, and such radiomics features may help quantify these patterns to predict Ki-67 PI of GISTs. Clinical relevance statement GIST may exhibit similar radiomics patterns irrespective of contrast agent; thus, radiomics models based on non-contrast-enhanced CT could be an alternative for risk stratification in GIST patients with contraindication to contrast agent. Key Points • Performance of radiomics models in predicting Ki-67 proliferation based on different CT phases is evaluated . • Non-contrast-enhanced CT–based radiomics models performed similarly to contrast-enhanced CT in risk stratification in GIST patients . • NGTDM Busyness remains stable to contrast agents in GISTs in radiomics models .
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
zhilianghui0807完成签到 ,获得积分10
1秒前
满天星辰独览完成签到 ,获得积分10
6秒前
白月光完成签到,获得积分10
7秒前
张大侠完成签到,获得积分20
8秒前
echo发布了新的文献求助20
8秒前
eee完成签到,获得积分10
15秒前
ybheart完成签到,获得积分0
16秒前
单纯乘风完成签到 ,获得积分10
17秒前
蔡从安完成签到,获得积分20
18秒前
且歌行完成签到,获得积分10
19秒前
cp3xzh完成签到,获得积分10
20秒前
哈哈哈完成签到 ,获得积分10
27秒前
咯咯咯完成签到 ,获得积分10
29秒前
活泼初之完成签到 ,获得积分10
31秒前
一个小菜鸡完成签到,获得积分10
32秒前
阿泽完成签到 ,获得积分10
38秒前
tt完成签到 ,获得积分10
39秒前
青黛完成签到 ,获得积分10
40秒前
后陡门的夏天完成签到 ,获得积分10
41秒前
月夕完成签到 ,获得积分10
43秒前
优秀的芯完成签到,获得积分10
46秒前
于洋完成签到 ,获得积分10
46秒前
小刘哥加油完成签到 ,获得积分10
48秒前
熊雅完成签到,获得积分10
52秒前
斯文败类应助一个小胖子采纳,获得10
57秒前
laohu完成签到,获得积分10
57秒前
59秒前
夏日香气完成签到 ,获得积分10
1分钟前
方方完成签到 ,获得积分10
1分钟前
鲜于雁芙完成签到 ,获得积分10
1分钟前
彭于晏应助科研通管家采纳,获得10
1分钟前
完美世界应助科研通管家采纳,获得10
1分钟前
华仔应助科研通管家采纳,获得10
1分钟前
1分钟前
chloe完成签到 ,获得积分10
1分钟前
忐忑的草丛完成签到,获得积分10
1分钟前
何博发布了新的文献求助10
1分钟前
1分钟前
echo完成签到,获得积分10
1分钟前
大机灵发布了新的文献求助10
1分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968559
求助须知:如何正确求助?哪些是违规求助? 3513391
关于积分的说明 11167370
捐赠科研通 3248808
什么是DOI,文献DOI怎么找? 1794465
邀请新用户注册赠送积分活动 875116
科研通“疑难数据库(出版商)”最低求助积分说明 804664