医学
烧蚀
肝细胞癌
荟萃分析
相对风险
放射科
超声波
经皮
导管消融
子群分析
科克伦图书馆
随机对照试验
射频消融术
置信区间
外科
内科学
作者
Yangang Sheng,Xueke Sun,Hong-Mei Sun,Jinyan Qi,Hua Li,Jiankui Luan,Deyin Zhai
标识
DOI:10.1177/02841851231187638
摘要
Background Ultrasound-guided percutaneous thermal ablation has become an alternative treatment for small hepatocellular carcinoma (HCC). Recent evidence suggests that fusion imaging (FI) may improve the feasibility and efficacy of thermal ablation for HCC, while the clinical evidence remains limited. Purpose To compare FI versus ultrasound-guided thermal ablation for HCC. Material and Methods Relevant cohort or randomized controlled trials were found by searching Medline, Web of Science, Cochrane Library, and Embase. The pooling of results was performed using a random-effects model incorporating heterogeneity. Results In this meta-analysis, 15 studies involving 1472 patients (1831 tumors) for FI-guided ablation and 1380 patients (1864 tumors) for ultrasound-guided ablation were included. Pooled results showed that compared to conventional HCC ablation guided by ultrasound, the FI-guided procedure showed a similar technique efficacy rate (risk ratio [RR] = 1.01, 95% confidence interval [CI] = 1.00–1.02, P = 0.25; I 2 = 30%). However, FI-guided tumor ablation was associated with a lower incidence of overall complications (RR = 0.70, 95% CI = 0.50–0.97, P = 0.03; I 2 = 0%). Moreover, patients receiving FI-guided tumor ablation had a lower risk of local tumor progression during follow-up than those with ultrasound-guided ablation (RR = 0.61, 95% CI = 0.47–0.78, P < 0.001; I 2 = 13%). Subgroup analysis according to FI strategy, imaging techniques in controls, and tumor diameter showed consistent results (p for subgroup difference all >0.05). Conclusion FI-guided thermal ablation may be more effective and safer than ultrasound-guided ablation for patients with HCC.
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