线粒体
疾病
重编程
发病机制
生物
生物信息学
粒线体疾病
细胞
线粒体融合
能量代谢
细胞代谢
医学
线粒体DNA
细胞生物学
免疫学
基因
病理
遗传学
内分泌学
作者
Xiaoyang Huang,Zhenhua Zeng,Siqi Li,Yufei Xie,Xiaoyong Tong
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2022-12-09
卷期号:14 (12): 2760-2760
被引量:12
标识
DOI:10.3390/pharmaceutics14122760
摘要
Cardiovascular disease (CVD) is a group of systemic disorders threatening human health with complex pathogenesis, among which mitochondrial energy metabolism reprogramming has a critical role. Mitochondria are cell organelles that fuel the energy essential for biochemical reactions and maintain normal physiological functions of the body. Mitochondrial metabolic disorders are extensively involved in the progression of CVD, especially for energy-demanding organs such as the heart. Therefore, elucidating the role of mitochondrial metabolism in the progression of CVD is of great significance to further understand the pathogenesis of CVD and explore preventive and therapeutic methods. In this review, we discuss the major factors of mitochondrial metabolism and their potential roles in the prevention and treatment of CVD. The current application of mitochondria-targeted therapeutic agents in the treatment of CVD and advances in mitochondria-targeted gene therapy technologies are also overviewed.
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