运动性
肠神经系统
生物
胃肠道
串扰
补体系统
细胞生物学
先天免疫系统
蠕动
小肠
免疫系统
免疫学
神经科学
解剖
生物化学
物理
光学
作者
Mihir Pendse,Haley De Selle,Nguyen Vo,Gabriella Quinn,Chaitanya Dende,Yun Li,Cristine N Salinas,Tarun Srinivasan,Daniel C. Propheter,Alexander A. Crofts,Eugene Koo,Brian Hassell,Kelly A. Ruhn,Prithvi Raj,Yuichi Obata,Lora V. Hooper
出处
期刊:eLife
[eLife Sciences Publications, Ltd.]
日期:2023-04-26
卷期号:12
被引量:3
摘要
Peristaltic movement of the intestine propels food down the length of the gastrointestinal tract to promote nutrient absorption. Interactions between intestinal macrophages and the enteric nervous system regulate gastrointestinal motility, yet we have an incomplete understanding of the molecular mediators of this crosstalk. Here, we identify complement component 1q (C1q) as a macrophage product that regulates gut motility. Macrophages were the predominant source of C1q in the mouse intestine and most extraintestinal tissues. Although C1q mediates the complement-mediated killing of bacteria in the bloodstream, we found that C1q was not essential for the immune defense of the intestine. Instead, C1q-expressing macrophages were located in the intestinal submucosal and myenteric plexuses where they were closely associated with enteric neurons and expressed surface markers characteristic of nerve-adjacent macrophages in other tissues. Mice with a macrophage-specific deletion of C1qa showed changes in enteric neuronal gene expression, increased neurogenic activity of peristalsis, and accelerated intestinal transit. Our findings identify C1q as a key regulator of gastrointestinal motility and provide enhanced insight into the crosstalk between macrophages and the enteric nervous system.
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