炎症
周细胞
生物
背景(考古学)
壁细胞
免疫学
细胞生物学
细胞因子
促炎细胞因子
纤维化
表型
白细胞贩卖
神经科学
病理
内皮干细胞
医学
趋化因子
体外
遗传学
古生物学
基因
作者
Samuel G. Rayner,Chi F. Hung,W. Conrad Liles,William A. Altemeier
出处
期刊:American Journal of Physiology-lung Cellular and Molecular Physiology
[American Physiological Society]
日期:2023-07-01
卷期号:325 (1): L1-L8
被引量:3
标识
DOI:10.1152/ajplung.00354.2022
摘要
Pericytes are microvascular mural cells that directly contact endothelial cells. They have long been recognized for their roles in vascular development and homeostasis, but more recently have been identified as key mediators of the host response to injury. In this context, pericytes possess a surprising degree of cellular plasticity, behaving dynamically when activated and potentially participating in a range of divergent host responses to injury. Although there has been much interest in the role of pericytes in fibrosis and tissue repair, their involvement in the initial inflammatory process has been understudied and is increasingly appreciated. Pericytes mediate inflammation through leukocyte trafficking and cytokine signaling, respond to pathogen-associated molecular patterns and tissue damage-associated molecular patterns, and may drive vascular inflammation during human SARS-CoV-2 infection. In this review, we highlight the inflammatory phenotype of activated pericytes during organ injury, with an emphasis on novel findings relevant to pulmonary pathophysiology.
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