Novel ZFPL1::NUP98 fusion gene identified in an adult acute myeloid leukemia patient

International Journal of Laboratory HematologyEarly View LETTER TO THE EDITOR Novel ZFPL1::NUP98 fusion gene identified in an adult acute myeloid leukemia patient Yiyan Zhu, Yiyan Zhu orcid.org/0000-0002-8610-2221 National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of ChinaSearch for more papers by this authorYu Chen, Yu Chen orcid.org/0000-0001-9933-8869 Department of Hematology, The Second Affiliated Hospital of Wannan Medical College, Wuhu, People's Republic of ChinaSearch for more papers by this authorFenghong Zhang, Fenghong Zhang orcid.org/0000-0001-5468-6341 National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of ChinaSearch for more papers by this authorMan Wang, Man Wang National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of ChinaSearch for more papers by this authorYueyun Lai, Yueyun Lai National Clinical Research Center for Hematologic Diseases, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University Institute of Hematology, Peking University People's Hospital, Peking University, Beijing, People's Republic of ChinaSearch for more papers by this authorJinlan Pan, Jinlan Pan National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of ChinaSearch for more papers by this authorYizi Liu, Yizi Liu National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of ChinaSearch for more papers by this authorQian Wang, Corresponding Author Qian Wang [email protected] National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China Correspondence Qian Wang and Suning Chen, National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China. Email: [email protected]; [email protected]Search for more papers by this authorSuning Chen, Corresponding Author Suning Chen [email protected] National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China Correspondence Qian Wang and Suning Chen, National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China. Email: [email protected]; [email protected]Search for more papers by this author Yiyan Zhu, Yiyan Zhu orcid.org/0000-0002-8610-2221 National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of ChinaSearch for more papers by this authorYu Chen, Yu Chen orcid.org/0000-0001-9933-8869 Department of Hematology, The Second Affiliated Hospital of Wannan Medical College, Wuhu, People's Republic of ChinaSearch for more papers by this authorFenghong Zhang, Fenghong Zhang orcid.org/0000-0001-5468-6341 National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of ChinaSearch for more papers by this authorMan Wang, Man Wang National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of ChinaSearch for more papers by this authorYueyun Lai, Yueyun Lai National Clinical Research Center for Hematologic Diseases, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Peking University Institute of Hematology, Peking University People's Hospital, Peking University, Beijing, People's Republic of ChinaSearch for more papers by this authorJinlan Pan, Jinlan Pan National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of ChinaSearch for more papers by this authorYizi Liu, Yizi Liu National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of ChinaSearch for more papers by this authorQian Wang, Corresponding Author Qian Wang [email protected] National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China Correspondence Qian Wang and Suning Chen, National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China. Email: [email protected]; [email protected]Search for more papers by this authorSuning Chen, Corresponding Author Suning Chen [email protected] National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People's Republic of China Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou, People's Republic of China Correspondence Qian Wang and Suning Chen, National Clinical Research Center for Hematologic Diseases, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou, China. Email: [email protected]; [email protected]Search for more papers by this author First published: 06 February 2024 https://doi.org/10.1111/ijlh.14239 Yiyan Zhu, Yu Chen, and Fenghong Zhang are co-first authors. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Open Research DATA AVAILABILITY STATEMENT The data supporting this study's findings are available from the corresponding author upon reasonable request. Supporting Information Filename Description ijlh14239-sup-0001-Supplementary_Tables.xlsxExcel 2007 spreadsheet , 12.4 KB Supplementary Table 1 Panel of partner fusion genes detected by targeted RNA sequencing. Supplementary Table 2 The result of RNA sequencing for ZFPL1::NUP98 fusion gene. Supplementary Table 3 X::NUP98 fusion gene of hematologic diseases reported in the literature. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. REFERENCES 1Papaemmanuil E, Gerstung M, Bullinger L, et al. Genomic classification and prognosis in acute myeloid leukemia. N Engl J Med. 2016; 374(23): 2209-2221. doi:10.1056/nejmoa1516192 10.1056/NEJMoa1516192 CASPubMedWeb of Science®Google Scholar 2Hollink IHIM, Van Den Heuvel-Eibrink MM, Arentsen-Peters STCJM, et al. NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern. 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