胶粘剂
生物相容性
材料科学
明胶
生物降解
光引发剂
聚合物
丙烯酸
组织粘连
自愈水凝胶
纳米技术
生物医学工程
粘附
高分子化学
化学
复合材料
有机化学
共聚物
医学
单体
图层(电子)
冶金
作者
Min Liang,Dandan Wei,Pengfei Ren,Li Xu,Yinghua Tao,Liuxin Yang,Gaofeng Jiao,Tianzhu Zhang,Takeshi Serizawa
标识
DOI:10.1002/adhm.202302538
摘要
Abstract Hydrogel adhesives with integrated functionalities are still required to match their ever‐expanding practical applications in the field of tissue repair and regeneration. A simple and effective safety strategy is reported, involving an in situ injectable polymer precursor and visible light‐induced cross‐linking. This strategy enables the preparation of a hydrogel adhesive in a physiological environment, offering wet adhesion to tissue surfaces, molecular flexibility, biodegradability, biocompatibility, efficient hemostatic performance, and the ability to facilitate liver injury repair. The proposed one‐step preparation process of this polymer precursor involves the mixing of gelatin methacryloyl (GelMA), poly(thioctic acid) [P(TA)], poly(acrylic acid)/amorphous calcium phosphate (PAAc/ACP, PA) and FDA‐approved photoinitiator solution, and a subsequent visible light irradiation after in situ injection into target tissues that resulted in a chemically‐physically cross‐linked hybrid hydrogel adhesive. Such a combined strategy shows promise for medical scenarios, such as uncontrollable post‐traumatic bleeding.
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