纳米技术
材料科学
离子键合
固体表面
表面电荷
表面改性
润湿
电流(流体)
化学物理
离子
化学
工程类
电气工程
有机化学
物理化学
复合材料
作者
Li Dai,Weiqi Zhang,D. Ding,Cihui Luo,Lei Jiang,Yu Huang,Fan Xia
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-03-07
卷期号:18 (11): 7677-7687
被引量:1
标识
DOI:10.1021/acsnano.3c12270
摘要
Solid-state nanochannel-based sensing systems have been established as vigorous tools for sensing plentiful biomarkers due to their label-free, highly sensitive, and high-throughput screening. However, research on solid-state nanochannels has predominantly centered on the functional groups modified on the inner wall, neglecting investigations into the outer surface. Actually, the outer surface, as a part of the nanochannels, also plays a key role in regulating ionic current. When the target nears the entrance of the nanochannel and prepares to pass through, it would also interact with functional groups located on the nanochannel's outer surface, leading to subsequent alterations in the ionic current. Recently, the probes on the outer surface have experimentally demonstrated their ability to independently regulate ionic current, unveiling advantages in in situ target detection, especially for targets larger than the diameter of the nanochannels that cannot pass through them. Here, we review the progress over the past decade in nanochannels featuring diverse outer-surface functionalization aimed at enhanced sensing performance, including charge modification, wettability adjustment, and probe immobilization. In addition, we present the promises and challenges posed by outer-surface functionalized nanochannels and discuss possible directions for their future deployments.
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