生物
增强子
表观遗传学
表观遗传学
基因
转录因子
计算生物学
遗传学
视网膜
基因表达调控
转录调控
基因调控网络
基因敲除
基因表达
神经科学
DNA甲基化
摘要
Genetic and expression studies have indicated that the development of vertebrate eyes is guided by a conserved gene regulatory network. The aim of the project was to study the role of selected transcription factors in neuroepithelium‐derived structures of the eye. We combined the power of mouse genetics via the use of conditional knockouts with molecular studies of transcriptional regulation through implementation of biochemical, transcriptomic and epigenomic approaches. In order to identify gene regulatory elements we generated genome‐wide occupancy data for a defined set of transcription factors using mouse embryonic retina as a sample. We will present our preliminary genetic data on functional validation of selected retina enhancers.
科研通智能强力驱动
Strongly Powered by AbleSci AI