增食欲素
神经科学
焦虑
神经肽
食欲素-A
警惕(心理学)
战斗或逃跑反应
调节器
心理学
生物
医学
内科学
精神科
生物化学
受体
基因
作者
Miklós Jászberényi,Balázs Thurzó,Zsolt Bagosi,László Vécsei,Masaru Tanaka
出处
期刊:Biomedicines
[MDPI AG]
日期:2024-02-17
卷期号:12 (2): 448-448
被引量:17
标识
DOI:10.3390/biomedicines12020448
摘要
The orexin/hypocretin neuropeptide family has emerged as a focal point of neuroscientific research following the discovery that this family plays a crucial role in a variety of physiological and behavioral processes. These neuropeptides serve as powerful neuromodulators, intricately shaping autonomic, endocrine, and behavioral responses across species. Notably, they serve as master regulators of vigilance and stress responses; however, their roles in food intake, metabolism, and thermoregulation appear complementary and warrant further investigation. This narrative review provides a journey through the evolution of our understanding of the orexin system, from its initial discovery to the promising progress made in developing orexin derivatives. It goes beyond conventional boundaries, striving to synthesize the multifaceted activities of orexins. Special emphasis is placed on domains such as stress response, fear, anxiety, and learning, in which the authors have contributed to the literature with original publications. This paper also overviews the advancement of orexin pharmacology, which has already yielded some promising successes, particularly in the treatment of sleep disorders.
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