头孢他啶/阿维巴坦
质粒
阿维巴坦
微生物学
肺炎克雷伯菌
突变
头孢他啶
医学
生物
细菌
基因
遗传学
铜绿假单胞菌
大肠杆菌
作者
Chengkang Tang,Siquan Shen,Weiwei Yang,Qingyu Shi,Li Ding,Renru Han,Fupin Hu
标识
DOI:10.1016/j.ijantimicag.2024.107228
摘要
The rapid dissemination of carbapenem-resistant Enterobacterales (CRE) especially carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a great threat to global public health. Ceftazidime-avibactam, a novel β-lactam/β-lactamase inhibitor combination, has been widely used due to its excellent antibacterial activity against KPC-producing K. pneumoniae. However, several resistance mechanisms have been reported since its use. Here, we conducted a series of in vitro experiments to reveal and demonstrate the dynamic evolution of ceftazidime-avibactam resistance including interspecies IncX3_NDM-5 plasmid transfer between Enterobacter cloacae and K. pneumoniae and bla
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