作者
Kenzo Ichimura,Mario Boehm,Adam Andruska,Fan Zhang,Katharina Schimmel,Spencer A. Bonham,Angela Kabiri,Vitaly O. Kheyfets,S Ichimura,Sushma Reddy,Yuqiang Mao,Tianyi Zhang,Gordon Wang,Everton José Santana,Xuefei Tian,Ilham Essafri,Ryan Vinh,Wen Tian,Mark R. Nicolls,Shin Yajima,Yasuhiro Shudo,John W. MacArthur,Y. Joseph Woo,Ross J. Metzger,Edda Spiekerkoetter
摘要
Pathogenic concepts of right ventricular (RV) failure in pulmonary arterial hypertension focus on a critical loss of microvasculature. However, the methods underpinning prior studies did not take into account the 3-dimensional (3D) aspects of cardiac tissue, making accurate quantification difficult. We applied deep-tissue imaging to the pressure-overloaded RV to uncover the 3D properties of the microvascular network and determine whether deficient microvascular adaptation contributes to RV failure.