The impact of choledochal cysts on bile fluid dynamics: A perspective using computational fluid dynamics and surface mapping technique

胆管 胆总管囊肿 剪应力 胆总管 医学 内科学 生物医学工程 机械 放射科 物理 囊肿
作者
Xueren Li,Xiaojian Ni,Wentao Sun,Jiaying Liu,Yidan Shang,Houbao Liu,Jiyuan Tu
出处
期刊:Physics of Fluids [American Institute of Physics]
卷期号:36 (6)
标识
DOI:10.1063/5.0206053
摘要

Choledochal cysts (CCs) are an important risk factor for cholangiocarcinoma, though their etiology remains debated. Given the vital role of bile fluid in digestive processes within the biliary system, examining such mechanisms from the perspective of bile fluid dynamics may offer additional insights for clinical use. This study utilized magnetic resonance imaging (MRI)-based patient-specific scans for detailed reconstruction and further employed the computational fluid dynamic method to assess the physiological functions of each system, including refilling and emptying processes. The impact of bile rheological property was also examined. Key biomechanical parameters—pressure and wall shear stress (WSS)—were displayed on a two-dimensional plane via surface mapping for enhanced visualization and comparative analysis. Outcomes demonstrated a significant reduction in bile flow velocity in CCs patients due to common bile duct's anatomical features and bile's shear-thinning, non-Newtonian nature, with a notable increase in pressure drop observed. In healthy biliary systems, WSS variations were minimal; however, in CCs patients, extreme WSS differences were found, with the highest WSS in the segmental bile duct and the lowest in the dilatation area, presenting a magnitude difference of approximately 1000. CCs one showed WSS levels 100–250 times higher than healthy ones in the common bile duct. Bile rheological properties substantially affect pressure and WSS patterns, particularly WSS, where pathological bile caused a tenfold increase in WSS compared to healthy bile. The findings aimed to enhance the understanding of biliary fluid mechanics in CCs and offer insights into selected fluidic variables for future microfluidic chip experiments.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
净禅完成签到 ,获得积分10
刚刚
dandan完成签到 ,获得积分10
2秒前
贾苏戏完成签到,获得积分20
4秒前
科研通AI2S应助不可靠月亮采纳,获得10
8秒前
伯赏凝旋完成签到 ,获得积分10
9秒前
13秒前
奋斗的丝完成签到 ,获得积分10
14秒前
斐然诗完成签到 ,获得积分10
15秒前
李健的小迷弟应助guojia采纳,获得30
17秒前
22秒前
25秒前
善良元芹完成签到 ,获得积分10
27秒前
28秒前
稳重完成签到 ,获得积分10
30秒前
苏苏完成签到 ,获得积分10
30秒前
汉堡包应助weng采纳,获得10
30秒前
香蕉觅云应助不可靠月亮采纳,获得10
34秒前
月儿发布了新的文献求助10
35秒前
高贵花瓣完成签到,获得积分10
40秒前
40秒前
1Yer6完成签到 ,获得积分10
40秒前
weng完成签到,获得积分10
42秒前
张尧摇摇摇完成签到 ,获得积分10
42秒前
ys1111完成签到 ,获得积分10
44秒前
北辰完成签到 ,获得积分10
44秒前
ys1111xiao完成签到 ,获得积分10
53秒前
mumuyayaguoguo完成签到 ,获得积分10
57秒前
57秒前
wBw完成签到,获得积分10
1分钟前
武大帝77完成签到 ,获得积分10
1分钟前
guojia发布了新的文献求助30
1分钟前
Driscoll完成签到 ,获得积分10
1分钟前
诗蕊完成签到 ,获得积分0
1分钟前
1分钟前
轩辕德地完成签到,获得积分10
1分钟前
如意竺完成签到,获得积分10
1分钟前
动听安筠完成签到 ,获得积分10
1分钟前
平淡小鸭子完成签到,获得积分10
1分钟前
666星爷完成签到,获得积分10
1分钟前
一三二五七完成签到 ,获得积分0
1分钟前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Smart but Scattered: The Revolutionary Executive Skills Approach to Helping Kids Reach Their Potential (第二版) 1000
Very-high-order BVD Schemes Using β-variable THINC Method 850
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3248865
求助须知:如何正确求助?哪些是违规求助? 2892249
关于积分的说明 8270316
捐赠科研通 2560537
什么是DOI,文献DOI怎么找? 1389048
科研通“疑难数据库(出版商)”最低求助积分说明 651004
邀请新用户注册赠送积分活动 627850