(Re)modeling high-salt diet-induced hypertension in mice

Editorial FocusConsidering Sex as a Biological Variable in Cardiovascular Research(Re)modeling high-salt diet-induced hypertension in miceGavin Power and Jaume PadillaGavin PowerDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United StatesNextGen Precision Health, University of Missouri, Columbia, Missouri, United States and Jaume PadillaDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri, United StatesNextGen Precision Health, University of Missouri, Columbia, Missouri, United StatesHarry S. Truman Memorial Veterans’ Hospital, Columbia, Missouri, United StatesPublished Online:10 Mar 2023https://doi.org/10.1152/ajpheart.00093.2023This is the final version - click for previous versionMoreSectionsFull TextPDF (256 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat REFERENCES1. Elijovich F, Kleyman TR, Laffer CL, Kirabo A. Immune mechanisms of dietary salt-induced hypertension and kidney disease: Harry Goldblatt Award for Early Career Investigators 2020. Hypertension 78: 252–260, 2021. doi:10.1161/HYPERTENSIONAHA.121.16495. Crossref | PubMed | Google Scholar2. Ertuglu LA, Mutchler AP, Yu J, Kirabo A. Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome. Front Physiol 13: 1096296, 2022. doi:10.3389/fphys.2022.1096296.Crossref | PubMed | Google Scholar3. Mattson DL, Dasinger JH, Abais-Battad JM. Gut-immune-kidney axis: influence of dietary protein in salt-sensitive hypertension. Hypertension 79: 2397–2408, 2022. doi:10.1161/HYPERTENSIONAHA.122.18556. Crossref | PubMed | ISI | Google Scholar4. Ishida A, Fujisawa M, Del Saz EG, Okumiya K, Kimura Y, Manuaba IIB, Kareth MF, Rantetampang AL, Ohya Y, Matsubayashi K. Arterial stiffness, not systolic blood pressure, increases with age in native Papuan populations. Hypertens Res 41: 539–546, 2018. doi:10.1038/s41440-018-0047-z. Crossref | PubMed | Google Scholar5. Gurven M, Blackwell AD, Rodríguez DE, Stieglitz J, Kaplan H. Does blood pressure inevitably rise with age?: longitudinal evidence among forager-horticulturalists. Hypertension 60: 25–33, 2012. doi:10.1161/HYPERTENSIONAHA.111.189100. Crossref | PubMed | ISI | Google Scholar6. Ishida A, Isotani A, Fujisawa M, Del Saz EG, Okumiya K, Kimura Y, Manuaba IIB, Rantetampang AL, Ohya Y, Matsubayashi K. Effects of a low-salt and high-potassium diet on arterial stiffness and left ventricular function in indigenous Papuans. J Am Heart Assoc 10: e021789, 2021. doi:10.1161/JAHA.121.021789.Crossref | PubMed | Google Scholar7. Oliver WJ, Cohen EI, Neel JV. Blood pressure, sodium intake, and sodium related hormones in the Yanomamo indians, a “no salt” culture. Circulation 52: 146–151, 1975. doi:10.1161/01.cir.52.1.146. Crossref | PubMed | ISI | Google Scholar8. Carrillo-Larco RM, Bernabe-Ortiz A. Sodium and salt consumption in Latin America and the Caribbean: a systematic-review and meta-analysis of population-based studies and surveys. Nutrients 12: 556, 2020. doi:10.3390/nu12020556. Crossref | PubMed | Google Scholar9. Wallace TC, Cowan AE, Bailey RL. Current sodium intakes in the United States and the modelling of glutamate’s incorporation into select savory products. Nutrients 11: 2691, 2019. doi:10.3390/nu11112691. Crossref | PubMed | Google Scholar10. Whelton PK, Appel LJ, Sacco RL, Anderson CAM, Antman EM, Campbell N, Dunbar SB, Frohlich ED, Hall JE, Jessup M, Labarthe DR, Macgregor GA, Sacks FM, Stamler J, Vafiadis DK, Van Horn LV. Sodium, blood pressure, and cardiovascular disease: further evidence supporting the American Heart Association sodium reduction recommendations. Circulation 126: 2880–2889, 2012. [Erratum in Circulation 27: e263, 2013]. doi:10.1161/CIR.0b013e318279acbf. Crossref | PubMed | ISI | Google Scholar11. Barris CT, Faulkner JL, De Chantemèle EJB. Salt sensitivity of blood pressure in women. Hypertension 80: 268–278, 2023. doi:10.1161/HYPERTENSIONAHA.122.17952. Crossref | PubMed | ISI | Google Scholar12. Hartner A, Cordasic N, Klanke B, Veelken R, Hilgers KF. Strain differences in the development of hypertension and glomerular lesions induced by deoxycorticosterone acetate salt in mice. Nephrol Dial Transplant 18: 1999–2004, 2003. doi:10.1093/ndt/gfg299. Crossref | PubMed | ISI | Google Scholar13. Leonard AM, Chafe LL, Montani JP, Van Vliet BN. Increased salt-sensitivity in endothelial nitric oxide synthase-knockout mice. Am J Hypertens 19: 1264–1269, 2006. doi:10.1016/j.amjhyper.2006.05.025. Crossref | PubMed | ISI | Google Scholar14. Dahl BYLK. Effects of chronic excess salt feeding. Induction of self-sustaining hypertension in rats. J Exp Med 114: 231–236, 1961. doi:10.1084/jem.114.2.231. Crossref | PubMed | Google Scholar15. Rapp JP. Dahl salt-susceptible and salt-resistant rats. Hypertension 4: 753–783, 1982. doi:10.1161/01.hyp.4.6.753. Crossref | PubMed | ISI | Google Scholar16. Luft FC. Rats, salt, and history. Cell Metab 15: 129–130, 2012. doi:10.1016/j.cmet.2012.01.007. Crossref | PubMed | Google Scholar17. Gavras H, Brunner HR, Laragh JH, Vaughan ED, Koss M, Cote LJ, Gavras I. Malignant hypertension resulting from deoxycorticosterone acetate and salt excess. Role of renin and sodium in vascular changes. Circ Res 36: 300–309, 1975. doi:10.1161/01.res.36.2.300. Crossref | PubMed | ISI | Google Scholar18. Kõks S, Dogan S, Tuna BG, González-Navarro H, Potter P, Vandenbroucke RE. Mouse models of ageing and their relevance to disease. Mech Ageing Dev 160: 41–53, 2016. doi:10.1016/j.mad.2016.10.001. Crossref | PubMed | Google Scholar19. Zheng X, Berg Sen J, Li Z, Sabouri M, Samarah L, Deacon CS, Bernado J, Machin DR. High-salt diet augments systolic blood pressure and induces arterial 2 dysfunction in outbred, genetically diverse mice. Am J Physiol Heart Circ Physiol 324: TBA, 2023. doi:10.1152/ajpheart.00415.2022. Link | Google Scholar20. Spronck B. Disentangling arterial stiffness and blood pressure. Heart Lung Circ 30: 1599–1601, 2021. doi:10.1016/j.hlc.2021.05.086. Crossref | PubMed | Google Scholar21. Wenceslau CF, McCarthy CG, Earley S, England SK, Filosa JA, Goulopoulou S, Gutterman DD, Isakson BE, Kanagy NL, Martinez-Lemus LA, Sonkusare SK, Thakore P, Trask AJ, Watts SW, Clinton Webb R. Guidelines for the measurement of vascular function and structure in isolated arteries and veins. Am J Physiol Heart Circ Physiol 321: H77–H111, 2021. doi:10.1152/ajpheart.01021.2020. Link | ISI | Google Scholar22. Qiu H, Zhu Y, Sun Z, Trzeciakowski JP, Gansner M, Depre C, Resuello RRG, Natividad FF, Hunter WC, Genin GM, Elson EL, Vatner DE, Meininger GA, Vatner SF. Short communication: Vascular smooth muscle cell stiffness as a mechanism for increased aortic stiffness with aging. Circ Res 107: 615–619, 2010. doi:10.1161/CIRCRESAHA.110.221846. Crossref | PubMed | ISI | Google Scholar23. Sehgel NL, Vatner SF, Meininger GA. Smooth muscle cell stiffness syndrome”-Revisiting the structural basis of arterial stiffness. Front Physiol 6: 335, 2015. doi:10.3389/fphys.2015.00335.Crossref | PubMed | ISI | Google Scholar24. Combe R, Mudgett J, Fertak LE, Champy MF, Ayme-Dietrich E, Petit-Demoulière B, Sorg T, Herault Y, Madwed JB, Monassier L. How does circadian rhythm impact salt sensitivity of blood pressure in mice? A study in two close C57Bl/6 substrains. PLoS One 11: e0153472, 2016. doi:10.1371/journal.pone.0153472. Crossref | PubMed | ISI | Google Scholar25. Ralph AF, Grenier C, Costello HM, Stewart K, Ivy JR, Dhaun N, Bailey MA. Activation of the sympathetic nervous system promotes blood pressure salt-sensitivity in C57BL6/J mice. Hypertension 77: 158–168, 2021. doi:10.1161/HYPERTENSIONAHA.120.16186. Crossref | PubMed | ISI | Google Scholar26. Kirabo A. A new paradigm of sodium regulation in inflammation and hypertension. Am J Physiol Regul Integr Comp Physiol 313: R706–R710, 2017. doi:10.1152/ajpregu.00250.2017. Link | ISI | Google Scholar27. Zheng X, Deacon C, King AJ, Machin DR. Microcirculatory and glycocalyx properties are lowered by high-salt diet but augmented by Western diet in genetically heterogeneous mice. Am J Physiol Heart Circ Physiol 322: H328–H335, 2022. doi:10.1152/ajpheart.00656.2021. Link | ISI | Google Scholar28. Foote CA, Soares RN, Ramirez‐Perez FI, Ghiarone T, Aroor A, Manrique‐Acevedo C, Padilla J, Martinez‐Lemus L. Endothelial glycocalyx. Compr Physiol 14: 3781–3811, 2022. doi:10.1002/cphy.c210029.Crossref | PubMed | Google Scholar29. Oberleithner H, Riethmüller C, Schillers H, MacGregor GA, De Wardener HE, Hausberg M. Plasma sodium stiffens vascular endothelium and reduces nitric oxide release. Proc Natl Acad Sci USA 104: 16281–16286, 2007. doi:10.1073/pnas.0707791104. Crossref | PubMed | ISI | Google Scholar30. Fels J, Jeggle P, Kusche-Vihrog K, Oberleithner H. Cortical actin nanodynamics determines nitric oxide release in vascular endothelium. PLoS One 7: e41520, 2012. doi:10.1371/journal.pone.0041520. Crossref | PubMed | Google Scholar31. Mutchler SM, Kirabo A, Kleyman TR. Epithelial sodium channel and salt-sensitive hypertension. Hypertension 77: 759–767, 2021. doi:10.1161/HYPERTENSIONAHA.120.14481. Crossref | PubMed | ISI | Google Scholar32. Zhang L, Yang Y, Aroor AR, Jia G, Sun Z, Parrish A, Litherland G, Bonnard B, Jaisser F, Sowers JR, Hill MA. Endothelial sodium channel activation mediates DOCA-salt-induced endothelial cell and arterial stiffening. Metabolism 130: 155165, 2022. doi:10.1016/j.metabol.2022.155165. Crossref | PubMed | Google Scholar Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation CollectionsAJP-Heart CollectionsIntegrative Cardiovascular Physiology and Pathophysiology Related ArticlesHigh-salt diet augments systolic blood pressure and induces arterial dysfunction in outbred, genetically diverse mice 10 Mar 2023American Journal of Physiology-Heart and Circulatory Physiology More from this issue > Volume 324Issue 4April 2023Pages H470-H472 Crossmark Copyright & PermissionsPublished by the American Physiological Society.https://doi.org/10.1152/ajpheart.00093.2023PubMed36827228History Received 17 February 2023 Accepted 21 February 2023 Published online 10 March 2023 Published in print 1 April 2023 Metrics