保护组
肽
肽合成
化学
胺气处理
氨基酸
羧酸
组合化学
酒
有机化学
生物化学
烷基
作者
Martin Conda‐Sheridan,Maddeboina Krishnaiah
出处
期刊:Methods in molecular biology
日期:2019-12-27
卷期号:: 111-128
被引量:12
标识
DOI:10.1007/978-1-0716-0227-0_7
摘要
The protection of amino acid reactive functionalities including the α-amino group, the side chain (amines, carboxylic acids, alcohols, and thiols), or the carboxylic acid terminus is an essential strategy in peptide chemistry. This is mandatory to prevent polymerization of the amino acids and to minimize undesirable side reactions during the synthetic process. Proper protecting group manipulation strategies can maximize the yield of the desired product or allow the construction of complex peptide-based structures. Thus, the compatibility and orthogonality of each protecting group are key to achieve the proper control of molecular structure. Herein, we describe some common protecting groups and their general unmasking methods, in order to mask and expose amine, carboxylic acid, alcohol, and thiol functionalities to achieve the synthesis of peptides and related molecules.
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