质粒
生物
遗传学
艰难梭菌
基因座(遗传学)
基因
染色体
多位点序列分型
毒力
微生物学
抗生素
基因型
作者
Junyan Liu,Peng Liang,Heng Su,Hai‐Xian Tang,Dingqiang Chen,Zhenbo Xu,Aiwu Wu
出处
期刊:Microbial Drug Resistance
[Mary Ann Liebert]
日期:2020-05-14
卷期号:26 (12): 1503-1508
被引量:6
标识
DOI:10.1089/mdr.2019.0461
摘要
Clostridioides difficile ST37 is an emerging and prevalent multilocus sequence type and represents a lineage of clinical significance. This study aimed to characterize two epidemic C. difficile ST37 strains, CD161 and CDT4. CD161 acquires a chromosome and two distinct plasmids, pCD161-L, sharing high similarity with Clostridium phage, and pCD161-S, while CDT4 has a chromosome and a plasmid pCDT4 identical to pCD161-S. In the chromosome of both strains, three CdISt1-like elements and a skinCd element, which might influence sporulation, were identified. The multidrug resistance of the strains was due to the mutation in 23S rDNA, gyrA, and gyrB genes and the acquisition of ermB, ant6-Ia, aac6'-aph2'', and tetM genes. In addition, a distinct pathogenicity locus (PaLoc) with truncated tcdA gene represents the genetic feature of ST37 strains. To our knowledge, this is the first complete genome, both chromosomes and plasmids, of epidemic C. difficile ST37 strains in China.
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