应用程序编程接口
规范化(社会学)
文档
基因相互作用
交互网络
接口(物质)
可药性
数据库
计算机科学
交互信息
资源(消歧)
生物
基因
数学
计算机网络
统计
生物化学
最大气泡压力法
人类学
社会学
气泡
并行计算
程序设计语言
作者
Sharon Freshour,Susanna Kiwala,Kelsy C. Cotto,Adam C. Coffman,Joshua F. McMichael,Jonathan J Song,Malachi Griffith,Alex H. Wagner
摘要
Abstract The Drug-Gene Interaction Database (DGIdb, www.dgidb.org) is a web resource that provides information on drug-gene interactions and druggable genes from publications, databases, and other web-based sources. Drug, gene, and interaction data are normalized and merged into conceptual groups. The information contained in this resource is available to users through a straightforward search interface, an application programming interface (API), and TSV data downloads. DGIdb 4.0 is the latest major version release of this database. A primary focus of this update was integration with crowdsourced efforts, leveraging the Drug Target Commons for community-contributed interaction data, Wikidata to facilitate term normalization, and export to NDEx for drug-gene interaction network representations. Seven new sources have been added since the last major version release, bringing the total number of sources included to 41. Of the previously aggregated sources, 15 have been updated. DGIdb 4.0 also includes improvements to the process of drug normalization and grouping of imported sources. Other notable updates include the introduction of a more sophisticated Query Score for interaction search results, an updated Interaction Score, the inclusion of interaction directionality, and several additional improvements to search features, data releases, licensing documentation and the application framework.
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