Environmental chemicals affect circadian rhythms: An underexplored effect influencing health and fitness in animals and humans

昼夜节律 生物 斑马鱼 时间生物学 达尼奥 生理学 神经科学 遗传学 基因
作者
Xuehan Zheng,Kun Zhang,Yanbin Zhao,Karl Fent
出处
期刊:Environment International [Elsevier]
卷期号:149: 106159-106159 被引量:56
标识
DOI:10.1016/j.envint.2020.106159
摘要

Circadian rhythms control the life of virtually all organisms. They regulate numerous aspects ranging from cellular processes to reproduction and behavior. Besides the light-dark cycle, there are additional environmental factors that regulate the circadian rhythms in animals as well as humans. Here, we outline the circadian rhythm system and considers zebrafish (Danio rerio) as a representative vertebrate organism. We characterize multiple physiological processes, which are affected by circadian rhythm disrupting compounds (circadian disrupters). We focus on and summarize 40 natural and anthropogenic environmental circadian disrupters in fish. They can be divided into six major categories: steroid hormones, metals, pesticides and biocides, polychlorinated biphenyls, neuroactive drugs and other compounds such as cyanobacterial toxins and bisphenol A. Steroid hormones as well as metals are most studied. Especially for progestins and glucocorticoids, circadian dysregulation was demonstrated in zebrafish on the molecular and physiological level, which comprise mainly behavioral alterations. Our review summarizes the current state of knowledge on circadian disrupters, highlights their risks to fish and identifies knowledge gaps in animals and humans. While most studies focus on transcriptional and behavioral alterations, additional effects and consequences are underexplored. Forthcoming studies should explore, which additional environmental circadian disrupters exist. They should clarify the underlying molecular mechanisms and aim to better understand the consequences for physiological processes.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
弄香发布了新的文献求助10
刚刚
刚刚
充电宝应助1234采纳,获得10
1秒前
YZJing完成签到,获得积分10
1秒前
1秒前
八块腹肌发布了新的文献求助10
1秒前
Rosemary完成签到,获得积分10
1秒前
白rain发布了新的文献求助20
2秒前
vivianzzz发布了新的文献求助20
2秒前
krkr发布了新的文献求助10
3秒前
5秒前
ZXj123发布了新的文献求助10
5秒前
5秒前
英姑应助Rosemary采纳,获得10
5秒前
5秒前
风中的双发布了新的文献求助10
6秒前
6秒前
8秒前
cavi发布了新的文献求助10
8秒前
mo0应助稳重向南采纳,获得20
8秒前
辛勤的乌发布了新的文献求助10
9秒前
我是魏有才完成签到,获得积分10
10秒前
小蘑菇应助zyc采纳,获得10
12秒前
在水一方应助弄香采纳,获得10
12秒前
123发布了新的文献求助10
12秒前
13秒前
13秒前
13秒前
13秒前
dreamon发布了新的文献求助10
13秒前
Luyao发布了新的文献求助10
13秒前
Owen应助不羁的风采纳,获得10
14秒前
14秒前
科目三应助大爱仙尊采纳,获得10
15秒前
15秒前
研友_8Wq6Mn完成签到 ,获得积分10
16秒前
彩色凉面完成签到,获得积分10
16秒前
黄阿鹏发布了新的文献求助10
17秒前
小董不懂发布了新的文献求助10
18秒前
19秒前
高分求助中
Sustainability in Tides Chemistry 2000
Microlepidoptera Palaearctica, Volumes 1 and 3 - 13 (12-Volume Set) [German] 1122
Дружба 友好报 (1957-1958) 1000
The Data Economy: Tools and Applications 1000
Mantiden - Faszinierende Lauerjäger – Buch gebraucht kaufen 600
PraxisRatgeber Mantiden., faszinierende Lauerjäger. – Buch gebraucht kaufe 600
A Dissection Guide & Atlas to the Rabbit 600
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3106352
求助须知:如何正确求助?哪些是违规求助? 2757369
关于积分的说明 7644699
捐赠科研通 2411634
什么是DOI,文献DOI怎么找? 1279512
科研通“疑难数据库(出版商)”最低求助积分说明 617805
版权声明 599271