表观遗传学
生物
基因组印记
内分泌系统
DNA甲基化
染色质
精子
组蛋白
生殖毒性
遗传学
毒性
细胞生物学
基因
基因表达
内科学
内分泌学
医学
激素
作者
Yanbin Shi,Wen Qi,Qi Xu,Zheng Wang,Xiaolian Cao,Liting Zhou,Lin Ye
摘要
Abstract Environmental endocrine disruptors (EEDs) seriously endanger human health by interfering with the normal function of reproductive systems. In males, EEDs can affect sperm formation and semen quality as well spermatogenesis, ultimately reducing fertility. In females, EEDs can affect uterine development and the expression levels of reproduction‐related genes, ultimately reducing female fertility and the normal development of the fetus. There are a large number of putative mechanisms by which EEDs can induce reproductive toxicity, and many studies have shown the involvement of epigenetics. In this review, we summarize the role of DNA methylation, noncoding RNAs, genomic imprinting, chromatin remodeling and histone modification in the reproductive toxicity of EEDs.
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