微泡
液体活检
外体
细胞外小泡
核酸
活检
胞外囊泡
病理
生物
细胞生物学
医学
癌症研究
小RNA
生物化学
癌症
遗传学
基因
作者
Biting Zhou,Kailun Xu,Xi Zheng,Ting Chen,Jian Wang,Yinjing Song,Yingkuan Shao,Shu Zheng
标识
DOI:10.1038/s41392-020-00258-9
摘要
Liquid biopsy refers to the sampling and molecular analysis of the biofluids of circulating tumor cells, extracellular vesicles, nucleic acids, and so forth. Exosomes are small extracellular vesicles with sizes between 30-150 nm. They are secreted by multivesicular bodies through exocytosis in live cells and can participate in intercellular communication due to their contents, including nucleic acids, proteins, and lipids. Herein, we investigate publication frequencies on exosomes over the past 10 years, and review recent clinical studies on liquid biopsy of exosomes in the fields of oncology, pregnancy disorders, cardiovascular diseases, and organ transplantation. We also describe the advantages of exosomes as an effective liquid biopsy tool and the progression of exosome extraction methods. Finally, we depict the commercial development of exosome research and discuss the future role of exosomes in liquid biopsy.
科研通智能强力驱动
Strongly Powered by AbleSci AI