Evaluation of Systematic Inflammation, Oxidative Stress and Endothelial Disfunction in COPD, ASTHMATIC AND ACO Patients with Obesity

Although COPD, asthma and obesity are characterised by chronic, systemic inflammation ,oxidative stress and endothelial disfunction, their interactions are poorly understood.The purpose of this study was to determine the concentrations of inflammatory, oxidative stress biomarkers and endothelial disfunction in the serum of COPD, asthmatic and ACO patients. Study included 86 obese patients (mean age 63.87 ± 10.1 years) divided into three groups: COPD (n=29) , asthma (n=22) and ACO (n=35). Measurements of serum levels of fibrinogen, high-sensitivity c-reactive protein (hs-CRP), eosinophils, TNF-alpha were done.We measured malondialdehyde (MDA) levels as a biomarker of oxidative stress. Soluble vascular cell adhesion molecule-1 (sVCAM-1) and endothelin-1 were measured as endothelial biomarkers. There were significant positive correlations between the plasma ET-1 level and CRP level in the whole study groups. The sVCAM-1 were found to be increased in COPD and ACO group, but was higher in the ACO group (3548,34± 250,70р<0,05). There was no difference in CRP level between groups, but MDA concentration was higher in the ACO group. The TNF-α and fibrinogen level was higher in the ACO group (730,54± 37,34 р<0,05 and 7,01±0,34<0,05 respectively).Patients with a higher grade of eosinophilia had a tendency towards lower CRP levels. Highest level of systemic inflammation and endothelial disfunction were found in the group of patients with ACO. Increased MDA concentration indicate excess of oxidative stress in ACO patients. Further research is needed to increase our knowledge of the disease and potentially identify new therapeutic goals.