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Identification of temporal pattern of mandibular condylar growth: a molecular and biochemical experiment

髁突 软骨内骨化 软骨 软骨发生 生物 解剖 化学 内分泌学
作者
Gang Shen,Urban Hägg,A. Bakr M. Rabie,Kumara Kaluarachchi
出处
期刊:Orthodontics & Craniofacial Research [Wiley]
卷期号:8 (2): 114-122 被引量:33
标识
DOI:10.1111/j.1601-6343.2005.00316.x
摘要

Structured Abstract Authors – Shen G, Hägg U, Rabie AB, Kaluarachchi K Objectives – Based on the phenomenon that expression of type X collagen and capillary endothelium correlates with endochondral ossification, the prime aim of this study was to establish the temporal pattern of condylar growth in Sprague–Dawley rats by biochemically identifying the expression of these two factors. Design – Sprague–Dawley rats were divided into five groups representing five different stages during somatic pubertal growth. In situ hybridization and immunoperoxidase were performed to examine expression of type X collagen in hypertrophic zone and capillary endothelium in erosive zone of condylar cartilage. Computer‐assisted imaging analyses were conducted to allow for a quantitative assessment of the expression of these two factors, from which the temporal pattern of condylar growth was inferred. Results – (1) Synthesis of type X collagen and emergence of capillary endothelium were critical factors during the transition of condylar cartilage from chondrogenesis into osteogenesis, a biological pathway that leads to endochondral bone formation, the mode through which the condyle grows. (2) Quantitative analyses revealed the temporal pattern of the expression of these two factors, indicating that the thrust of natural growth of the condyle in the rats occurred in concomitance with somatic pubertal growth, featured by an acceleration starting from day 38, a maximum growth rate on day 56, followed by a decrease afterwards. Conclusion – It is suggested that the biochemical examination of growth markers, such as type X collagen, might be a new approach to accurately depict temporal pattern of condylar growth which is too delicate to be reflected by gross measurement not only in Sprague–Dawley rats but potentially also in other species.
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