A controlled clinical investigation of 3% diclofenac/2.5% sodium hyaluronate topical gel in the treatment of uncontrolled pain in chronic oral NSAID users with osteoarthritis.
Topical application, 4 times daily for 2 weeks, of the diclofenac-hyaluronan gel to 59 osteoarthritis patients induced a significantly greater (p = 0.057) analgesic effect than placebo gel lacking the active substance applied to 60 control patients.