Kinetic Resolution of (R,S)-atenolol with the Use of Lipases in Various Organic Solvents

Aim and Objective: The enzymatic method are used for the direct resolution of racemic atenolol. The catalytic activities of nine commercially available lipases were firstly compared, then all enzymes were tested for the kinetic resolution of (R,S)-atenolol by enantioselective acetylation in different reaction mediums. Additionally, the effects of the acetylating agent and its concentration were also investigated. The most effective conversion and the best enantioselectivity were achieved using lipase from Candida rugosa (OF). Keywords: Enzymatic, (R, S)-atenolol, kinetic resolution, enantioselective acetylation, Candida rugosa, organic solvent.