The Effect Of Piracetam On Liver Damage In Dogs Submitted To Hemorrhagic Shock

Background: To investigate the effect of piracetam on liver damage in dogs submitted to hemorrhagic shock. Methods: The subjects were randomized into four subgroups each consisting of 10 dogs. Hemorrhagic shock was caused in Group I for 1 hour and no treatment was given to this group. Blood and saline solutions were administered to Group II following 1 hour hemorrhagic shock. Blood and piracetam were given to Group III following 1 hour shock. No shock was caused and no treatment was applied to Group IV. Blood samples were obtained at the onset of the experiment at 60, 120 and 180 minutes for lactate, arterial blood gases, bicarbonate, aspartate transaminase and alanine transaminase analysis. For histopathological examination, liver tissue samples were obtained at the end of the experiment.Results: It was observed that the improvement in lactate, aspartate transaminase and alanine transaminase levels in Group III was more than Group II. It was seen that the recovery in liver damage in Group III was greater than control group. Conclusion: Piracetam, added to the treatment, may decrease liver damage in hemorrhagic shock.