艾灸
前额叶皮质
扣带回前部
扣带皮质
方差分析
后扣带
静息状态功能磁共振成像
医学
神经科学
认知
丘脑
功能连接
心理学
内科学
听力学
病理
中枢神经系统
针灸科
替代医学
作者
Chengxiang Li,Lihua Zhao,Ke Xu,Yichen Wei,Weiyi Mai,Lan Liang,Ruiqing Piao,Bowen Geng,Shuming Zhang,Demao Deng,Peng Liu
出处
期刊:Brain Research
[Elsevier]
日期:2022-01-01
卷期号:1775: 147732-147732
被引量:7
标识
DOI:10.1016/j.brainres.2021.147732
摘要
Mild cognitive impairment (MCI) is a general neurodegenerative disease. Moxibustion has been shown to have remarkable effect on cognitive improvement, however, less is known about the effect of moxibustion on MCI and its underlying neural mechanism. This study aimed to investigate the ameliorative brain network in MCI after treatments of acupoint-related moxibustion.Resting-state functional MRI were derived from 47 MCI patients and 30 healthy controls (HCs). Patients were randomized as Tiaoshen YiZhi (TSYZ, n = 27) and sham (SHAM, n = 20) acupoint moxibustion groups. Functional connectivity density (FCD) method and repeated-measures two-way analysis of variance (ANOVA) were performed to ascertain the interaction effects between groups (TSYZ and SHAM) and time (baseline and post-treatment). Abnormal FCD was examined between baseline and post-treatment in TSYZ and SHAM groups, respectively.Compared with HCs, MCI showed altered FCD in the middle frontal cortex (MFC), inferior frontal cortex, temporal pole, thalamus and middle cingulate cortex. After moxibustion treatment in MCI, 1) a significant time-by-groups interaction was observed in the medial prefrontal cortex (mPFC); 2) abnormal long-range FCD (lrFCD) in the mPFC and MFC were modulated in TSYZ group; 3) significantly improved clinical symptoms; 4) changed lrFCD in the MFC was significantly negatively correlated with the increased Montreal Cognitive Assessment scores in TSYZ group.These imaging findings suggest that treatments of acupoint-related moxibustion could improve lrFCD in certain regions related to self-related cognitive and decision making. Our study might promote understanding of MCI neural mechanisms and expand the clinical application of moxibustion in MCI.
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