Cellulose nanofibril as a crosslinker to reinforce the sodium alginate/chitosan hydrogels

自愈水凝胶 壳聚糖 肿胀 的 化学工程 材料科学 纤维素 动态力学分析 聚合物 高分子化学 化学 复合材料 工程类
作者
Wangfang Deng,Yanjun Tang,Jiangchun Mao,Yiming Zhou,Tianying Chen,Xiangxue Zhu
出处
期刊:International Journal of Biological Macromolecules [Elsevier]
卷期号:189: 890-899 被引量:63
标识
DOI:10.1016/j.ijbiomac.2021.08.172
摘要

Hydrogels derived from natural polymers have received great attention, but their practical applications are severely hindered by the relatively poor mechanical properties. In this work, cellulose nanofibril (CNF) was used as a crosslinker to reinforce the sodium alginate (SA)/chitosan (CS) hydrogels for drug sustained release. The CNF was prepared via a combined process of ball milling and deep eutectic solvents (DESs) pretreatment and characterized using SEM, FT-IR, and XRD. Furthermore, the microstructure, mechanical/biological properties and swelling performance of SA/CS/CNF hydrogels were investigated. Results showed that 1.0 wt% CNF addition led to the increases of 23.6% in storage modulus and 54.4% in loss modulus for the SA/CS/CNF hydrogels, indicating that CNF addition was effective in reinforcing the three-dimensional entangled networks of the hydrogels. Moreover, the presence of CNF was found to weaken the swelling performance of SA/CS/CNF hydrogels. When the synthesized SA/CS/CNF hydrogel with 1.0 wt% CNF was applied as a carrier for drug release, 50.8% reduction in the release rate in simulated gastric juice was achieved, demonstrating its outstanding sustained release properties. This work suggested that CNF might be conducive to enhancing the properties of SA/CS hydrogels, which can serve as an ideal polymeric carrier for drug release.
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