精子无力症
男性不育
精子活力
生物
不育
精液
蛋白质组
男科
精子
蛋白质组学
精液分析
运动性
生物信息学
细胞生物学
遗传学
医学
怀孕
作者
Xiaodan Cao,Yun Cui,Xiaoxia Zhang,Lou Jiangtao,Jun Zhou,Hua-Feng Bei,Renxiong Wei
标识
DOI:10.1186/s12958-018-0334-1
摘要
Asthenozoospermia is considered as a common cause of male infertility and characterized by reduced sperm motility. However, the molecular mechanism that impairs sperm motility remains unknown in most cases. In the present review, we briefly reviewed the proteome of spermatozoa and seminal plasma in asthenozoospermia and considered post-translational modifications in spermatozoa of asthenozoospermia. The reduction of sperm motility in asthenozoospermic patients had been attributed to factors, for instance, energy metabolism dysfunction or structural defects in the sperm-tail protein components and the differential proteins potentially involved in sperm motility such as COX6B, ODF, TUBB2B were described. Comparative proteomic analysis open a window to discover the potential pathogenic mechanisms of asthenozoospermia and the biomarkers with clinical significance.
科研通智能强力驱动
Strongly Powered by AbleSci AI