Mechanochemical Synthesis of Phosphinecarboxamides by Reaction of 2‐Phosphaethynolate Anion and Amines under Acid‐Free Conditions: A Combined Scope and Mechanism Investigation

The reaction of the 2‐phosphaethynolate anion and primary amines for the mechanochemical synthesis of phosphinecarboxamides was studied. The reaction has its own merits, such as rapid reaction rate, high yield, mild and acid‐free conditions. The mechanochemical strategy offers a solvent‐free reaction environment with real‐time monitoring of the parameters, optimizing the reaction conditions and studying the mechanism without requiring further workup. The mechanism was investigated with use of IR, 13 C NMR, and 31 P NMR spectroscopy.