Dedifferentiated Chordoma in a 53-year-old Female: A Case Report

Dedifferentiated Chordomas are rare variants of a malignant bone tumor arising from remnants of the embryonal notochord.Most cases are reported from chordomas that have recurred after surgical resection and/or radiation.Dedifferentiated Chordomas have an overall poorer prognosis compared with conventional chordomas due to their highly aggressive behavior and high metastatic potential.We report a case of a Dedifferentiated Chordoma from the sacrum in a 53-year-old female with no known prior surgery or radiation treatment.The associated clinical and radiologic features are discussed along with a review of the reported cases in the English literature.The diagnostic pitfalls and approach for Chordomas as well as the current and developing treatment modalities are also reviewed.