Effect of creatine supplementation during resistance training on lean tissue mass and muscular strength in older adults: a meta-analysis

肌酸 瘦体质量 肌萎缩 医学 阻力训练 台式压力机 体力 压腿机 安慰剂 一水肌酸 力量训练 物理疗法 肌肉团 荟萃分析 随机对照试验 内科学 肌肉组织 体重 病理 替代医学
作者
Philip D. Chilibeck,Mojtaba Kaviani,Darren G. Candow,Gordon A. Zello
出处
期刊:Open access journal of sports medicine [Dove Medical Press]
卷期号:Volume 8: 213-226 被引量:172
标识
DOI:10.2147/oajsm.s123529
摘要

Abstract: The loss of muscle mass and strength with aging results in significant functional impairment. Creatine supplementation has been used in combination with resistance training as a strategy for increasing lean tissue mass and muscle strength in older adults, but results across studies are equivocal. We conducted a systematic review and meta-analysis of randomized controlled trials of creatine supplementation during resistance training in older adults with lean tissue mass, chest press strength, and leg press strength as outcomes by searching PubMed and SPORTDiscus databases. Twenty-two studies were included in our meta-analysis with 721 participants (both men and women; with a mean age of 57–70 years across studies) randomized to creatine supplementation or placebo during resistance training 2–3 days/week for 7–52 weeks. Creatine supplementation resulted in greater increases in lean tissue mass (mean difference =1.37 kg [95% CI =0.97–1.76]; p <0.00001), chest press strength (standardized mean difference [SMD] =0.35 [0.16–0.53]; p =0.0002), and leg press strength (SMD =0.24 [0.05–0.43]; p =0.01). A number of mechanisms exist by which creatine may increase lean tissue mass and muscular strength. These are included in a narrative review in the discussion section of this article. In summary, creatine supplementation increases lean tissue mass and upper and lower body muscular strength during resistance training of older adults, but potential mechanisms by which creatine exerts these positive effects have yet to be evaluated extensively. Keywords: muscle, age, sarcopenia, exercise, nutrition, bench press, leg press
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