Progressive degeneration of white matter functional connectivity in Alzheimer’s disease

白质 神经影像学 穹窿 神经科学 疾病 神经功能成像 静息状态功能磁共振成像 功能磁共振成像 心理学 阿尔茨海默病神经影像学倡议 功能连接 阿尔茨海默病 医学 磁共振成像 病理 海马体 放射科
作者
Yurui Gao,Muwei Li,Zhongliang Zu,Baxter P. Rogers,Adam W. Anderson,Zhaohua Ding,John C. Gore
标识
DOI:10.1117/12.2512919
摘要

Background: Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder, in which pathological alterations are seen in both gray matter (GM) and white matter (WM). To date functional MRI (fMRI) studies of AD have been exclusively focused on GM, since blood oxygenation level dependent (BOLD) signals in WM are relatively weak and thus ignored in practice. Our recent work provides compelling evidence that BOLD fluctuations in brain WM are reliably detectable and reflect neural activities, offering the potential of investigating the functional connectivity in WM. Purpose: In this study, we aim to apply our fMRI analysis method to the investigation of functional alterations in WM during the progression of AD. Method: Raw resting state fMRI data of normal subjects and patients (total n=290, 5 diagnostic groups) were obtained from the Alzheimer’s Disease Neuroimaging Initiative database. Each fMRI image was parcellated into 82 GM regions and 48 WM bundles. Temporal correlation between each pair of GM and WM was calculated and the correlations of all pairs constituted a functional correlation matrix (FCM) for each subject. The FCMs were averaged within each diagnostic group, and differences in the averaged FCMs between the normal group and each disease group were sought. Result: Differences in functional correlations progressively enlarge as the disease evolves, and fornix and ventral entorhinal cortices exhibited most pronounced differences between the normal and disease groups. Conclusion: Functional connectivity in WM may serve as a novel neuroimaging biomarker for the progression of AD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Lucas应助冷酷的格尔曼采纳,获得10
1秒前
neWA完成签到,获得积分10
2秒前
Emma发布了新的文献求助10
2秒前
3秒前
科目三应助111采纳,获得10
4秒前
熙欢发布了新的文献求助20
5秒前
LJF发布了新的文献求助10
5秒前
6秒前
李爱国应助Tsui采纳,获得10
7秒前
所所应助chao采纳,获得10
7秒前
Rank发布了新的文献求助10
8秒前
9秒前
9秒前
10秒前
小二郎应助宫冷雁采纳,获得10
11秒前
magicjerry发布了新的文献求助10
12秒前
天天开心发布了新的文献求助10
12秒前
14秒前
14秒前
15秒前
寂寞的诗云完成签到,获得积分10
15秒前
LJF完成签到,获得积分10
15秒前
16秒前
爆米花应助落寞之云采纳,获得10
17秒前
17秒前
CCC完成签到 ,获得积分10
17秒前
17秒前
18秒前
Cassie发布了新的文献求助10
20秒前
20秒前
天天开心完成签到,获得积分10
20秒前
21秒前
yujie发布了新的文献求助200
21秒前
宫冷雁发布了新的文献求助10
21秒前
22秒前
趣多多发布了新的文献求助10
22秒前
22秒前
难过千易发布了新的文献求助10
23秒前
dengyan完成签到,获得积分10
23秒前
思源应助coco采纳,获得10
23秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975375
求助须知:如何正确求助?哪些是违规求助? 3519700
关于积分的说明 11199305
捐赠科研通 3256034
什么是DOI,文献DOI怎么找? 1798049
邀请新用户注册赠送积分活动 877386
科研通“疑难数据库(出版商)”最低求助积分说明 806305