Cold gelation of curcumin loaded whey protein aggregates mixed with k-carrageenan: Impact of gel microstructure on the gastrointestinal fate of curcumin

姜黄素 卡拉胶 微观结构 乳清蛋白 化学 自愈水凝胶 豌豆蛋白 色谱法 化学工程 食品科学 有机化学 生物化学 结晶学 工程类
作者
Farhad Alavi,Zahra Emam‐Djomeh,Mohammad Saeid Yarmand,Maryam Salami,Shima Momen,Ali Akbar Moosavi‐Movahedi
出处
期刊:Food Hydrocolloids [Elsevier]
卷期号:85: 267-280 被引量:151
标识
DOI:10.1016/j.foodhyd.2018.07.012
摘要

This study aimed to design mixed hydrogels composed of whey protein aggregates (WPA)/k-carrageenan with a tailored microstructure to protect curcumin within the upper gastrointestinal tract and deliver it to the colon. Curcumin was loaded in WPA and followed by cold gelation of the aggregates in the presence of k-carrageenan. The Microstructure of the hydrogels varied from homogenous to protein continuous or k-carrageenan continuous depending on the k-carrageenan concentration (0.0, 0.1 and 0.55%, w/w). The physical stability of curcumin toward precipitation during gelation of curcumin-loaded WPA was significantly improved after k-carrageenan addition. The higher capacity of k-carrageenan containing gels to curcumin entrapment was attributed to curcumin embedment inside of the rich-protein microdomains (called microgels), higher viscosity of the gel pre-solutions contained k-carrageenan and the shorter gelation time of the corresponding gels. Moreover, it was found about 31% of the loaded curcumin was released in the simulated gastrointestinal tract for pure WPA gels, while after addition of 0.55% k-carrageenan to WPA gels, more than 87% of loaded curcumin were delivered to the colon. Besides, 33% of curcumin degraded after the gastrointestinal digestion, while for WPA gels containing 0.1% and 0.55% k-carrageenan it was only 9.6% and 3.5%, respectively. The results were attributed to the protective effect of k-carrageenan to protein during in vitro digestion so that the access of digestive enzymes into the hydrogels was limited resulting in a reduction of gel matrix erosion and curcumin release. Therefore, curcumin remained bound to the protein and was not damaged during digestion until it reaches the colon.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
动听怀莲完成签到,获得积分10
刚刚
xuxu完成签到,获得积分10
1秒前
2秒前
3秒前
动听怀莲发布了新的文献求助10
3秒前
4秒前
aniver发布了新的文献求助10
5秒前
彘shen完成签到 ,获得积分10
5秒前
6秒前
劲秉应助lixinyue采纳,获得50
6秒前
shain给shain的求助进行了留言
6秒前
7秒前
SSS发布了新的文献求助10
8秒前
8秒前
mark163发布了新的文献求助10
10秒前
10秒前
zhuo W完成签到,获得积分10
10秒前
bkagyin应助lirs采纳,获得10
10秒前
rcrc111完成签到 ,获得积分10
10秒前
样子完成签到,获得积分10
11秒前
12秒前
Owen应助ABS采纳,获得10
12秒前
蒹葭发布了新的文献求助10
13秒前
言兼完成签到,获得积分10
15秒前
liu123发布了新的文献求助10
15秒前
16秒前
aaa应助奋斗的寒蕾采纳,获得10
18秒前
星辰大海应助锂炸采纳,获得10
18秒前
俊逸海豚完成签到 ,获得积分10
18秒前
yi蔚发布了新的文献求助10
18秒前
英姑应助谭显芝采纳,获得10
18秒前
hhhs完成签到,获得积分10
18秒前
xyhua925完成签到,获得积分10
19秒前
yoyo完成签到,获得积分10
20秒前
吴路发布了新的文献求助10
20秒前
20秒前
田様应助liu123采纳,获得10
21秒前
21秒前
zambda完成签到,获得积分10
22秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
安全防范技术与工程 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3191096
求助须知:如何正确求助?哪些是违规求助? 2840441
关于积分的说明 8028444
捐赠科研通 2503796
什么是DOI,文献DOI怎么找? 1337185
科研通“疑难数据库(出版商)”最低求助积分说明 638034
邀请新用户注册赠送积分活动 606486