已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Cold gelation of curcumin loaded whey protein aggregates mixed with k-carrageenan: Impact of gel microstructure on the gastrointestinal fate of curcumin

姜黄素 卡拉胶 微观结构 乳清蛋白 化学 自愈水凝胶 豌豆蛋白 色谱法 化学工程 食品科学 有机化学 生物化学 结晶学 工程类
作者
Farhad Alavi,Zahra Emam‐Djomeh,Mohammad Saeid Yarmand,Maryam Salami,Shima Momen,Ali Akbar Moosavi‐Movahedi
出处
期刊:Food Hydrocolloids [Elsevier]
卷期号:85: 267-280 被引量:151
标识
DOI:10.1016/j.foodhyd.2018.07.012
摘要

This study aimed to design mixed hydrogels composed of whey protein aggregates (WPA)/k-carrageenan with a tailored microstructure to protect curcumin within the upper gastrointestinal tract and deliver it to the colon. Curcumin was loaded in WPA and followed by cold gelation of the aggregates in the presence of k-carrageenan. The Microstructure of the hydrogels varied from homogenous to protein continuous or k-carrageenan continuous depending on the k-carrageenan concentration (0.0, 0.1 and 0.55%, w/w). The physical stability of curcumin toward precipitation during gelation of curcumin-loaded WPA was significantly improved after k-carrageenan addition. The higher capacity of k-carrageenan containing gels to curcumin entrapment was attributed to curcumin embedment inside of the rich-protein microdomains (called microgels), higher viscosity of the gel pre-solutions contained k-carrageenan and the shorter gelation time of the corresponding gels. Moreover, it was found about 31% of the loaded curcumin was released in the simulated gastrointestinal tract for pure WPA gels, while after addition of 0.55% k-carrageenan to WPA gels, more than 87% of loaded curcumin were delivered to the colon. Besides, 33% of curcumin degraded after the gastrointestinal digestion, while for WPA gels containing 0.1% and 0.55% k-carrageenan it was only 9.6% and 3.5%, respectively. The results were attributed to the protective effect of k-carrageenan to protein during in vitro digestion so that the access of digestive enzymes into the hydrogels was limited resulting in a reduction of gel matrix erosion and curcumin release. Therefore, curcumin remained bound to the protein and was not damaged during digestion until it reaches the colon.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
zhangjianzeng发布了新的文献求助20
刚刚
Jian发布了新的文献求助30
1秒前
3秒前
金刚经应助沉静的八宝粥采纳,获得10
4秒前
4秒前
5秒前
Hello应助吵吵robot采纳,获得10
5秒前
sutharsons应助科研通管家采纳,获得30
5秒前
酷波er应助科研通管家采纳,获得10
5秒前
小二郎应助科研通管家采纳,获得20
5秒前
5秒前
独特的鹅完成签到,获得积分10
6秒前
花花发布了新的文献求助10
9秒前
史小菜应助summerkid采纳,获得10
9秒前
ddd发布了新的文献求助10
11秒前
13秒前
NexusExplorer应助花花采纳,获得10
13秒前
14秒前
edsenone发布了新的文献求助50
14秒前
李健应助水逆消退采纳,获得10
15秒前
zhangjianzeng发布了新的文献求助10
16秒前
天真的不凡完成签到 ,获得积分10
18秒前
黎云发布了新的文献求助10
18秒前
23秒前
ddfighting发布了新的文献求助10
23秒前
23秒前
呵呵心情发布了新的文献求助10
24秒前
sarmad应助ddd采纳,获得10
25秒前
XiaoXiao发布了新的文献求助10
28秒前
菜大鸭发布了新的文献求助10
28秒前
完美世界应助Creator12345666采纳,获得10
29秒前
29秒前
Jian完成签到,获得积分10
29秒前
研友_ZGRvon完成签到,获得积分0
30秒前
31秒前
Lumos完成签到,获得积分10
31秒前
耍酷的凡灵完成签到,获得积分10
32秒前
蛀牙联盟发布了新的文献求助10
33秒前
孤独师完成签到,获得积分10
33秒前
cy0824完成签到 ,获得积分10
34秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
India's foreign trade policy and its performance in the world economy 450
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196434
求助须知:如何正确求助?哪些是违规求助? 2845181
关于积分的说明 8053289
捐赠科研通 2509844
什么是DOI,文献DOI怎么找? 1342009
科研通“疑难数据库(出版商)”最低求助积分说明 639304
邀请新用户注册赠送积分活动 608565