Cold gelation of curcumin loaded whey protein aggregates mixed with k-carrageenan: Impact of gel microstructure on the gastrointestinal fate of curcumin

姜黄素 卡拉胶 微观结构 乳清蛋白 化学 自愈水凝胶 豌豆蛋白 色谱法 化学工程 食品科学 有机化学 生物化学 结晶学 工程类
作者
Farhad Alavi,Zahra Emam‐Djomeh,Mohammad Saeid Yarmand,Maryam Salami,Shima Momen,Ali Akbar Moosavi‐Movahedi
出处
期刊:Food Hydrocolloids [Elsevier]
卷期号:85: 267-280 被引量:151
标识
DOI:10.1016/j.foodhyd.2018.07.012
摘要

This study aimed to design mixed hydrogels composed of whey protein aggregates (WPA)/k-carrageenan with a tailored microstructure to protect curcumin within the upper gastrointestinal tract and deliver it to the colon. Curcumin was loaded in WPA and followed by cold gelation of the aggregates in the presence of k-carrageenan. The Microstructure of the hydrogels varied from homogenous to protein continuous or k-carrageenan continuous depending on the k-carrageenan concentration (0.0, 0.1 and 0.55%, w/w). The physical stability of curcumin toward precipitation during gelation of curcumin-loaded WPA was significantly improved after k-carrageenan addition. The higher capacity of k-carrageenan containing gels to curcumin entrapment was attributed to curcumin embedment inside of the rich-protein microdomains (called microgels), higher viscosity of the gel pre-solutions contained k-carrageenan and the shorter gelation time of the corresponding gels. Moreover, it was found about 31% of the loaded curcumin was released in the simulated gastrointestinal tract for pure WPA gels, while after addition of 0.55% k-carrageenan to WPA gels, more than 87% of loaded curcumin were delivered to the colon. Besides, 33% of curcumin degraded after the gastrointestinal digestion, while for WPA gels containing 0.1% and 0.55% k-carrageenan it was only 9.6% and 3.5%, respectively. The results were attributed to the protective effect of k-carrageenan to protein during in vitro digestion so that the access of digestive enzymes into the hydrogels was limited resulting in a reduction of gel matrix erosion and curcumin release. Therefore, curcumin remained bound to the protein and was not damaged during digestion until it reaches the colon.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
魏魏完成签到,获得积分10
刚刚
Tina泽发布了新的文献求助10
刚刚
sparks发布了新的文献求助10
1秒前
1秒前
不配.应助Gjj采纳,获得10
1秒前
科研通AI2S应助欢喜火车采纳,获得10
1秒前
4秒前
Shayulajiao完成签到,获得积分10
5秒前
5秒前
7秒前
8秒前
8秒前
8秒前
9秒前
斯文败类应助GeminiWU采纳,获得10
10秒前
Tina泽完成签到,获得积分10
10秒前
学术射手发布了新的文献求助50
10秒前
wsy发布了新的文献求助100
11秒前
cheese完成签到,获得积分10
11秒前
Lucas应助六七七采纳,获得10
11秒前
今后应助大猫喵喵喵采纳,获得10
12秒前
充电宝应助欢呼的冰蝶采纳,获得10
12秒前
陈陈陈完成签到,获得积分10
14秒前
jc发布了新的文献求助10
14秒前
14秒前
赘婿应助独特的宝川采纳,获得10
14秒前
含蓄元冬完成签到 ,获得积分10
14秒前
cheese发布了新的文献求助10
14秒前
ZYX完成签到,获得积分10
15秒前
大模型应助Fancy采纳,获得10
15秒前
17秒前
AJ完成签到 ,获得积分10
18秒前
18秒前
科目三应助啾啾采纳,获得10
18秒前
ZYX发布了新的文献求助10
19秒前
why发布了新的文献求助10
21秒前
学术妲己发布了新的文献求助10
22秒前
学无止境发布了新的文献求助10
22秒前
songnvshi完成签到 ,获得积分10
24秒前
25秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189181
求助须知:如何正确求助?哪些是违规求助? 2838612
关于积分的说明 8020271
捐赠科研通 2501388
什么是DOI,文献DOI怎么找? 1335575
科研通“疑难数据库(出版商)”最低求助积分说明 637634
邀请新用户注册赠送积分活动 605685