光遗传学
神经调节
计算机科学
无线
数码产品
功率(物理)
电池(电)
电气工程
工程类
电信
神经科学
物理
刺激
量子力学
生物
作者
Philipp Gutruf,Vaishnavi Krishnamurthi,Abraham Vázquez‐Guardado,Zhaoqian Xie,Anthony Banks,Chun-Ju Su,Yeshou Xu,Chad R. Haney,Emily A. Waters,Irawati Kandela,Siddharth Krishnan,Tyler R. Ray,John P. Leshock,Yonggang Huang,Debashis Chanda,John A. Rogers
标识
DOI:10.1038/s41928-018-0175-0
摘要
Recently developed ultrasmall, fully implantable devices for optogenetic neuromodulation eliminate the physical tethers associated with conventional set-ups and avoid the bulky head-stages and batteries found in alternative wireless technologies. The resulting systems allow behavioural studies without motion constraints and enable experiments in a range of environments and contexts, such as social interactions. However, these devices are purely passive in their electronic design, thereby precluding any form of active control or programmability; independent operation of multiple devices, or of multiple active components in a single device, is, in particular, impossible. Here we report optoelectronic systems that, through developments in integrated circuit and antenna design, provide low-power operation, and position- and angle-independent wireless power harvesting, with full user-programmability over individual devices and collections of them. Furthermore, these integrated platforms have sizes and weights that are not significantly larger than those of previous, passive systems. Our results qualitatively expand options in output stabilization, intensity control and multimodal operation, with broad potential applications in neuroscience research and, in particular, the precise dissection of neural circuit function during unconstrained behavioural studies. An optoelectronic platform that operates at low power and uses position- and angle-independent wireless power harvesting can provide multimodal programmable control over optogenetic stimulation parameters.
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