药剂学
金属有机骨架
纳米技术
药物输送
环糊精
材料科学
化学
吸附
有机化学
药理学
医学
作者
Yaoyao Han,Weicong Liu,Jianjing Huang,Shuowen Qiu,Huarui Zhong,Dong Liu,Jian-Qiang Liu
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2018-12-12
卷期号:10 (4): 271-271
被引量:122
标识
DOI:10.3390/pharmaceutics10040271
摘要
Metal-organic frameworks (MOFs) show promising application in biomedicine and pharmaceutics owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs are prepared from non-renewable or toxic materials, which limit their real-world applications. Cyclodextrins (CDs) are a typical natural and biodegradable cyclic oligosaccharide and are primarily used to enhance the aqueous solubility, safety, and bioavailability of drugs by virtue of its low toxicity and highly flexible structure, offering a peculiar ability to form CD/drug inclusions. A sophisticated strategy where CD is deployed as a ligand to form an assembly of cyclodextrin-based MOFs (CD-MOFs) may overcome real-world application drawbacks of MOFs. CD-MOFs incorporate the porous features of MOFs and the encapsulation capability of CD for drug molecules, leading to outstanding properties when compared with traditional hybrid materials. This review focuses on the inclusion technology and drug delivery properties associated with CD-MOFs. In addition, synthetic strategies and currently developed uses of CD-MOFs are highlighted as well. Also, perspectives and future challenges in this rapidly developing research area are discussed.
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