光热治疗
纳米载体
阿霉素
药物输送
吲哚青绿
体内
氢氧化物
化疗
纳米颗粒
化学
体外
纳米技术
癌症研究
材料科学
医学
生物化学
内科学
有机化学
病理
生物技术
生物
作者
Yuhan Ye,David H. Bremner,Hongmei Zhang,Xia Chen,Jiadong Lou,Li‐Min Zhu
标识
DOI:10.1016/j.colsurfb.2021.112261
摘要
In this work, a novel layered double hydroxide (LDH)-based multifunctional nanoplatform was built for synergistic photothermal therapy (PTT)/chemotherapy. The platform was modified using the peptide B3int to target cancer cells with overexpression of integrin αvβ3. Indocyanine green (ICG) and doxorubicin (DOX) were loaded into the nanocarrier (LDH-PEG-B3int NPs) to form a system having a high drug loading (18.62%) and a remarkable photothermal conversion efficiency of 25.38%. It also showed pH-responsive and near-infrared (NIR)-triggered DOX release. In vitro and in vivo studies indicated that the anti-tumor activity of the combined delivery system was significantly higher than that of a single delivery system. This co-delivery nanosystem may be helpful for future application in the clinical treatment of cancer.
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