置信区间
医学
科克伦图书馆
维生素E
体质指数
子群分析
荟萃分析
内科学
肥胖
随机对照试验
维生素D与神经学
维生素
胃肠病学
内分泌学
抗氧化剂
化学
生物化学
作者
Vali Musazadeh,Arash Tandorost,Meysam Zarezadeh,Jaber Jafarzadeh,Zoha Ghavami,Parsa Jamilian,Alireza Ostadrahimi
出处
期刊:International Journal for Vitamin and Nutrition Research
[Hogrefe Publishing Group]
日期:2022-07-07
标识
DOI:10.1024/0300-9831/a000757
摘要
Abstract. Background: Studies have shown that vitamin E as an antioxidant protects omega-3 fatty acids (FAs) from oxidation. Several studies have evaluated the effect of omega-3 FAs and vitamin E co-supplementation on obesity indices; however, the results are inconsistent. The present systematic review and meta-analysis was conducted to address the role of omega-3 FAs plus vitamin E on obesity indices. Methods: Cochrane Library, PubMed, Scopus, Embase, and Web of Science databases were searched up to February 2022. Among all of the qualified studies, 10 articles were selected. The effect size was presented as weighted mean difference (WMD) and 95% confidence interval (CI). Fixed-effects model was employed to perform meta-analysis. Subgroup analysis and publication bias assessment were carried out. Results: Ten eligible randomized controlled trials comprising 558 participants were included. The average dose of omega-3 FAs and vitamin E co-supplementation in studies was 1000–4000 mg/day and 400 IU, respectively. Intervention duration varied from 6 to 16 weeks. There was no significant effect of omega-3 and vitamin E co-supplementation on body weight (BW) (WMD=0.14 kg; 95% CI: −0.13 to 0.42; p=0.297), and body mass index (BMI) (WMD=0.08, 95% CI: −0.01 to 0.16, p=0.073). However, subgroup analysis showed that it might increase BMI in women over 50 years and if the intervention lasted more than 8 weeks. Conclusion: There was no significant impact of combined omega-3 FAs and vitamin E supplementation on BW and BMI; however, it should be noted that the intervention has an increasing impact when supplementation duration was >8 weeks and in individuals with type 2 diabetes mellitus, >50 years old, and BMI>25.
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