Polystyrene microplastics exacerbate experimental colitis in mice tightly associated with the occurrence of hepatic inflammation

炎症 炎症性肠病 结肠炎 医学 微塑料 粘液 溃疡性结肠炎 肠道通透性 胃肠病学 免疫学 内科学 疾病 生物 生态学
作者
Ting Luo,Dou Wang,Yao Zhao,Xinfang Li,Guiling Yang,Yuanxiang Jin
出处
期刊:Science of The Total Environment [Elsevier]
卷期号:844: 156884-156884 被引量:32
标识
DOI:10.1016/j.scitotenv.2022.156884
摘要

The potential health effects of microplastics (MPs) have become a public concern due to their ubiquitousness in the environment and life. Numerous studies have demonstrated that a high dose of MPs can adversely affect gastrointestinal health. However, few studies have focused on the impact of microplastics on patients' health with respect to gastrointestinal diseases. Inflammatory bowel disease (IBD) has emerged as a global disease with a rapidly increasing incidence. IBD, a specific gastrointestinal illness characterized by acute, chronic inflammation and intestinal barrier dysfunction, might increase sensitivity to MPs exposure. Herein, we investigated the impact and mechanism of PS-MPs on dextran sodium sulfate (DSS)-induced colitis. The results demonstrated that gavage with PS-MPs alone caused minimal effects on the intestinal barrier and liver status of mice. For mice with colitis, additional PS-MPs exposure caused a shorter colon length, aggravated histopathological damage and inflammation, reduced mucus secretion, and increased the colon permeability. Furthermore, PS-MPs exposure also increased the risk of secondary liver injury associated with inflammatory cell infiltration. These findings provide more histopathological evidence and suggest a need for more research on the health risk of MPs for sensitive individuals.
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