自闭症
地中海饮食法
四分位数
医学
逻辑回归
自闭症谱系障碍
分位数回归
量表
人口学
后代
怀孕
环境卫生
精神科
内科学
生物
置信区间
社会学
数学
统计
遗传学
作者
Rachel Vecchione,Siwen Wang,Juliette Rando,Jorge E. Chavarro,Lisa Croen,M. Daniele Fallin,Irva Hertz‐Picciotto,Craig J. Newschaffer,Rebecca J. Schmidt,Kristen Lyall
出处
期刊:Nutrients
[MDPI AG]
日期:2022-06-30
卷期号:14 (13): 2729-2729
被引量:4
摘要
We examined the relationship between maternal intake of established dietary patterns and child autism-related outcomes in two prospective cohorts in the United States. Participants were drawn from the Early Autism Risk Longitudinal Investigation (EARLI, n = 154) and the Nurses’ Health Study II (NHSII, n = 727). Dietary information was collected via food frequency questionnaires (FFQs) and used to calculate the empirical dietary inflammatory pattern (EDIP), Alternative Healthy Eating Index (AHEI), Western and Prudent dietary patterns, and the alternative Mediterranean Diet (aMED) score. Primary analyses examined associations with continuous autism-related traits as measured by the Social Responsiveness Scale (SRS), and secondary analyses with autism spectrum disorder (ASD) diagnosis. We used crude and multivariable quantile regression fixed at the 50th percentile to examine associations between quartiles of dietary patterns and SRS scores, and logistic regression to examine associations with ASD diagnosis. There was suggestion of a positive association with the Western diet (Q4 vs. Q1, ß = 11.19, 95% CI: 3.30, 19.90) in EARLI, though the association was attenuated with adjustment for total energy intake, and no clear associations were observed with other dietary patterns and ASD diagnosis or SRS scores. Further work is needed to better understand the role of maternal dietary patterns in ASD and related outcomes.
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