已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Mouse Liver B Cells Phagocytose <i>Streptococcus pneumoniae</i> and Initiate Immune Responses against Their Antigens

生物 免疫系统 体细胞突变 脾脏 肺炎链球菌 B-1电池 微生物学 吞噬作用 免疫球蛋白类转换 白细胞介素12 抗原 免疫学 B细胞 抗体
作者
Masahiro Nakashima,Manabu Kinoshita,Hiroyuki Nakashima,Azusa Kato,Kazuma Mori,Kazuki Koiwai,Nariyoshi Shinomiya,Shuhji Seki
出处
期刊:Journal of Immunology [The American Association of Immunologists]
卷期号:209 (1): 26-37
标识
DOI:10.4049/jimmunol.2100520
摘要

Recent studies have revealed that mammalian B cells ingest particulate Ags, such as bacteria, although little is known about the effect of this function on acquired immunity. We investigated the role of bacterium-phagocytosing B cells in acquired host immune responses. Cultured mouse liver B cells substantially phagocytosed serum-opsonized Streptococcus pneumoniae and produced IgM. On adoptive transfer of liver B cells that phagocytose S. pneumoniae labeled with pHrodo Red succinimidyl ester, recipient mice showed elevated plasma levels of IgG specific for bacterial Ags. In particular, the levels of IgG2a and IgG2b specific for pneumococcal surface protein A, as well as IgG3 for pneumococcal polysaccharide, were markedly increased compared with total IgG specific for each Ag. When phagocytic liver B cells were cultured with spleen CD4+ T cells obtained from mice primed with heat-killed S. pneumoniae 7 d before, they induced IL-2 production and proliferation of the CD4+ T cells, along with Th1 cytokine production. However, they induced neither the CD4+ T cell production of IL-21, a suggested marker promoting B cell proliferation and differentiation, nor the expression of genes important for somatic hypermutation or isotype switching; such responses were particularly evident when splenic B cells merely capturing S. pneumoniae without processing them were cultured with spleen CD4+ T cells. These findings suggest that phagocytic liver B cells may be involved in acquired immune responses by presenting derivative peptides to CD4+ T cells without their own somatic hypermutation or isotype switching.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Moonpie完成签到,获得积分10
1秒前
烟花应助幽幽采纳,获得10
1秒前
嘉心糖完成签到,获得积分0
4秒前
大泥鳅发布了新的文献求助10
5秒前
难过大神完成签到 ,获得积分10
7秒前
机灵的衬衫完成签到 ,获得积分10
8秒前
8秒前
10秒前
爱唱歌的yu仔完成签到,获得积分10
10秒前
10秒前
可靠从云完成签到 ,获得积分10
14秒前
善学以致用应助livialiu采纳,获得10
16秒前
16秒前
幽幽发布了新的文献求助10
16秒前
kid1912应助香山叶正红采纳,获得10
18秒前
Ahhhh123完成签到,获得积分20
21秒前
白天科室黑奴and晚上实验室牛马完成签到 ,获得积分10
21秒前
张土豆完成签到 ,获得积分10
22秒前
22秒前
24秒前
科研通AI2S应助稗子采纳,获得10
26秒前
怕黑香氛完成签到 ,获得积分10
29秒前
DSUNNY完成签到 ,获得积分10
29秒前
wild_cube完成签到 ,获得积分10
29秒前
kingtongx发布了新的文献求助30
29秒前
31秒前
打打应助迪迪采纳,获得10
33秒前
Billy应助科研通管家采纳,获得10
33秒前
在水一方应助科研通管家采纳,获得10
33秒前
汉堡包应助科研通管家采纳,获得10
33秒前
33秒前
m1nt完成签到,获得积分10
33秒前
hollow完成签到 ,获得积分10
34秒前
kid1912应助香山叶正红采纳,获得10
34秒前
小张完成签到 ,获得积分10
37秒前
38秒前
上官若男应助Ahhhh123采纳,获得10
39秒前
水心完成签到 ,获得积分10
39秒前
39秒前
44秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
安全防范技术与工程 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Актуализированная стратиграфическая схема триасовых отложений Прикаспийского региона. Объяснительная записка 360
Dictionary of socialism 350
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3192376
求助须知:如何正确求助?哪些是违规求助? 2841591
关于积分的说明 8034031
捐赠科研通 2505200
什么是DOI,文献DOI怎么找? 1338425
科研通“疑难数据库(出版商)”最低求助积分说明 638336
邀请新用户注册赠送积分活动 606881