已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Mouse Liver B Cells Phagocytose <i>Streptococcus pneumoniae</i> and Initiate Immune Responses against Their Antigens

生物 免疫系统 体细胞突变 脾脏 肺炎链球菌 B-1电池 微生物学 吞噬作用 免疫球蛋白类转换 白细胞介素12 抗原 免疫学 B细胞 抗体
作者
Masahiro Nakashima,Manabu Kinoshita,Hiroyuki Nakashima,Azusa Kato,Kazuma Mori,Kazuki Koiwai,Nariyoshi Shinomiya,Shuhji Seki
出处
期刊:Journal of Immunology [The American Association of Immunologists]
卷期号:209 (1): 26-37
标识
DOI:10.4049/jimmunol.2100520
摘要

Recent studies have revealed that mammalian B cells ingest particulate Ags, such as bacteria, although little is known about the effect of this function on acquired immunity. We investigated the role of bacterium-phagocytosing B cells in acquired host immune responses. Cultured mouse liver B cells substantially phagocytosed serum-opsonized Streptococcus pneumoniae and produced IgM. On adoptive transfer of liver B cells that phagocytose S. pneumoniae labeled with pHrodo Red succinimidyl ester, recipient mice showed elevated plasma levels of IgG specific for bacterial Ags. In particular, the levels of IgG2a and IgG2b specific for pneumococcal surface protein A, as well as IgG3 for pneumococcal polysaccharide, were markedly increased compared with total IgG specific for each Ag. When phagocytic liver B cells were cultured with spleen CD4+ T cells obtained from mice primed with heat-killed S. pneumoniae 7 d before, they induced IL-2 production and proliferation of the CD4+ T cells, along with Th1 cytokine production. However, they induced neither the CD4+ T cell production of IL-21, a suggested marker promoting B cell proliferation and differentiation, nor the expression of genes important for somatic hypermutation or isotype switching; such responses were particularly evident when splenic B cells merely capturing S. pneumoniae without processing them were cultured with spleen CD4+ T cells. These findings suggest that phagocytic liver B cells may be involved in acquired immune responses by presenting derivative peptides to CD4+ T cells without their own somatic hypermutation or isotype switching.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
精明紫雪完成签到,获得积分10
3秒前
ww完成签到,获得积分10
3秒前
Endless完成签到,获得积分10
5秒前
5秒前
suodeheng完成签到,获得积分10
6秒前
amber完成签到 ,获得积分10
8秒前
stuffmatter应助Endless采纳,获得30
9秒前
甘木鸣完成签到 ,获得积分10
12秒前
1111111发布了新的文献求助20
12秒前
不想读书发布了新的文献求助10
12秒前
科研通AI2S应助reck采纳,获得10
14秒前
Jokic完成签到,获得积分10
15秒前
April完成签到 ,获得积分10
15秒前
科研通AI2S应助缓慢的凝云采纳,获得10
17秒前
稚气满满完成签到 ,获得积分10
18秒前
美罗培南完成签到,获得积分10
19秒前
airsh发布了新的文献求助10
21秒前
大帅比完成签到 ,获得积分10
22秒前
仁爱钢笔完成签到 ,获得积分10
22秒前
suchashing完成签到 ,获得积分10
22秒前
24秒前
122完成签到 ,获得积分10
27秒前
嘎嘎发布了新的文献求助10
27秒前
姆姆没买完成签到 ,获得积分10
27秒前
fubi发布了新的文献求助30
28秒前
Ghiocel完成签到,获得积分10
30秒前
30秒前
汉堡包应助科研通管家采纳,获得30
30秒前
科研通AI2S应助科研通管家采纳,获得10
30秒前
Akim应助科研通管家采纳,获得10
30秒前
NNN7完成签到,获得积分10
30秒前
miana完成签到,获得积分10
31秒前
31秒前
Hasee完成签到 ,获得积分10
32秒前
小段完成签到,获得积分10
33秒前
中中发布了新的文献求助10
33秒前
酸番茄完成签到 ,获得积分10
33秒前
爆米花应助橙子快跑采纳,获得10
35秒前
在水一方应助务实涔雨采纳,获得10
35秒前
38秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189796
求助须知:如何正确求助?哪些是违规求助? 2839102
关于积分的说明 8022927
捐赠科研通 2501966
什么是DOI,文献DOI怎么找? 1336188
科研通“疑难数据库(出版商)”最低求助积分说明 637804
邀请新用户注册赠送积分活动 605852