A frequency-reconfigurable open-loop antenna based on liquid metal alloy (LMA) is proposed in this work. The Polymethylmethacrylate (PMMA) structure with two channels is loaded on the substrate of F4BM, providing a condition for frequency-reconfigurable. The lower frequency band can be obtained by injecting LMA into the outer channel and higher frequency band can be obtained by injecting LMA into inner channel. The Simulated impedance bandwidth ranges from 2.08-2.12 GHz and 3.5-3.59 GHz, respectively.