Preparation of anti ‐1,3‐Amino Alcohol Derivatives through an Asymmetric Aldol‐Tishchenko Reaction of Sulfinimines

Abstract Procedures yielding ( S )‐2‐Methyl‐ N ‐(1‐phenylethylidene)propane‐2‐sulfinamide 3 as two fractions of a yellow solid and (1 S ,3 S )‐1‐((( S )‐ tert ‐butylsulfinyl)amino)‐4‐methyl‐1‐phenylpentan‐3‐yl isobutyrate as a pale yellow oil are presented. A discussion on 1,3‐aminoalcohols as useful synthetic intermediates and building blocks concludes the chapter.